探索慢性化疗引起周围神经病变的癌症幸存者使用镇痛药的模式。

IF 1.6 4区 医学 Q2 NURSING Oncology nursing forum Pub Date : 2024-08-15 DOI:10.1188/24.ONF.445-450
Robert Knoerl, Michael B Sohn, Melyssa Foust, Lori Francar, Mark A O'Rourke, Gary M Morrow, Karen M Mustian, Lynn Gauthier, Jennifer S Gewandter
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引用次数: 0

摘要

目的探讨癌症幸存者过去和现在使用镇痛剂治疗慢性化疗引起的周围神经病变(CIPN)的情况:142名接受过神经毒性化疗并患有中度至重度CIPN的癌症治疗后幸存者:参与者在基线时填写了治疗诱发神经病变评估量表,并报告了用于控制 CIPN 的所有止痛药。对慢性 CIPN 过去或现在使用处方镇痛剂的频率进行描述,并根据 CIPN 疼痛的严重程度进行分层:基线时,31%的参与者报告曾使用过 CIPN 止痛药,46%的参与者目前正在使用 CIPN 止痛药。加巴喷丁是过去(20%)和现在(34%)最常用的镇痛药,度洛西汀的使用频率较低(6%过去使用,10%现在使用)。许多有严重疼痛的参与者(59%)报告说,他们使用镇痛药来治疗 CIPN:杜洛西汀是治疗慢性 CIPN 疼痛的一线药物,但其使用频率低于加巴喷丁,而加巴喷丁是治疗神经病理性疼痛的常用处方镇痛药。需要进一步开展研究,以确定在临床实践中推广实施循证 CIPN 治疗的策略。
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Exploring Analgesic Use Patterns Among Cancer Survivors With Chronic Chemotherapy-Induced Peripheral Neuropathy.

Objectives: To explore cancer survivors' historical and current use of analgesics for chronic chemotherapy-induced peripheral neuropathy (CIPN).

Sample & setting: 142 post-treatment cancer survivors who received neurotoxic chemotherapy and were experiencing moderate to severe CIPN.

Methods & variables: Participants completed the Treatment-Induced Neuropathy Assessment Scale at baseline and reported all analgesics used to manage CIPN. Frequency of historical or current prescription analgesic use for chronic CIPN was described and stratified by CIPN pain severity.

Results: At baseline, 31% of participants reported historical use of analgesics for CIPN and 46% of participants were currently using analgesics for CIPN. Gabapentin was the most frequently used analgesic, historically (20%) and currently (34%), and duloxetine was used less frequently (6% historical use, 10% current use). Many participants with severe pain (59%) reported using analgesics for CIPN.

Implications for nursing: Duloxetine, the first-line treatment for chronic CIPN pain, was used less frequently than gabapentin, a common prescription analgesic for neuropathic pain. Further research is needed to determine strategies to promote the implementation of evidence-based CIPN treatments in clinical practice.

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来源期刊
Oncology nursing forum
Oncology nursing forum 医学-护理
CiteScore
3.20
自引率
0.00%
发文量
76
审稿时长
>12 weeks
期刊介绍: The mission of the Oncology Nursing Forum, an official publication of ONS, is to Convey research information related to practice, technology, education, and leadership. Disseminate oncology nursing research and evidence-based practice to enhance transdisciplinary quality cancer care. Stimulate discussion of critical issues relevant to oncology nursing.
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