兽医关注的主要物种的内源性大麻素系统和植物大麻素:比较综述。

IF 1.8 3区 农林科学 Q2 VETERINARY SCIENCES Veterinary Research Communications Pub Date : 2024-10-01 Epub Date: 2024-08-20 DOI:10.1007/s11259-024-10509-7
Alessandra Di Salvo, Elisabetta Chiaradia, Monica Sforna, Giorgia Della Rocca
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引用次数: 0

摘要

自从内源性大麻素系统被发现以来,由于有实证表明服用外源性大麻素(即植物大麻素)对人类和动物的多种疾病具有治疗效果,因此进行了大量研究。这些研究旨在确定不同动物物种的健康和病理器官及组织中大麻素受体的表达和分布,并确定植物大麻素与这些受体的相互作用。在过去十年中,还研究了许多大麻衍生物制剂(主要含有大麻二酚)在兽医关注的主要物种中的药代动力学、功效和耐受性。本手稿概述了迄今为止发表的科学研究结果,这些研究涉及主要植物大麻素的分子作用模式、大麻素受体在器官和组织中的定位,以及大麻衍生物在狗、猫、马和其他兽医关注物种中的药代动力学、药效和耐受性。深入了解这些问题对于将植物大麻素用于动物物种的治疗至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Endocannabinoid system and phytocannabinoids in the main species of veterinary interest: a comparative review.

Since the discovery of the endocannabinoid system and due to the empirical evidence of the therapeutic effects on several illnesses both in humans and animals that follow the administration of exogenous cannabinoids (i.e., phytocannabinoids), numerous studies have been conducted. These investigations aimed to identify the expression and distribution of cannabinoid receptors in healthy and pathologic organs and tissues of different animal species and to define the interactions of phytocannabinoids with these receptors. In the last decade, pharmacokinetics, efficacy and tolerability of many Cannabis derivatives formulations, mainly containing cannabidiol, in the main species of veterinary interest, have been also investigated. This manuscript summarizes the findings reported by the scientific studies published so far on the molecular mode of action of the main phytocannabinoids, the localization of cannabinoid receptors in organs and tissues, as well as the pharmacokinetics, efficacy and tolerability of Cannabis derivatives in dogs, cats, horses and other species of veterinary interest. A deep knowledge of these issues is crucial for the use of phytocannabinoids for therapeutic purposes in animal species.

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来源期刊
Veterinary Research Communications
Veterinary Research Communications 农林科学-兽医学
CiteScore
2.50
自引率
0.00%
发文量
173
审稿时长
3 months
期刊介绍: Veterinary Research Communications publishes fully refereed research articles and topical reviews on all aspects of the veterinary sciences. Interdisciplinary articles are particularly encouraged, as are well argued reviews, even if they are somewhat controversial. The journal is an appropriate medium in which to publish new methods, newly described diseases and new pathological findings, as these are applied to animals. The material should be of international rather than local interest. As it deliberately seeks a wide coverage, Veterinary Research Communications provides its readers with a means of keeping abreast of current developments in the entire field of veterinary science.
期刊最新文献
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