{"title":"偶氮基菲啶配位的铜（II）催化剂在无水介质中用于胆固醇的电化学氧化","authors":"","doi":"10.1016/j.ica.2024.122305","DOIUrl":null,"url":null,"abstract":"<div><p>The synthesis of original 6-(azol-1-yl)phenanthridine ligands and a copper(II) complex based on them is reported. Comprehensive studies of the structural, physicochemical, and electrocatalytic properties for the selected 6-(1<em>H</em>-pyrazol-1-yl)phenanthridine-containing coordination compound have been carried out. The latter has demonstrated pronounced electrochemical and electrocatalytic activities in the enzyme-free cholesterol oxidation in DMSO. A six-stage mechanism including electrocatalytic reduction of cholesterol and subsequent oxidation of its reduction products has been proposed and underpinned by quantum mechanical considerations. Obtained analytical characteristics of the enzyme-free cholesterol oxidation (LoD 0.0032 mM, detectable concentrations 0.01–0.40 mM) open a prospect towards the investigated complexes to be applied as sensitive elements of portable electrochemical platforms for the point-of-care diagnostics.</p></div>","PeriodicalId":13599,"journal":{"name":"Inorganica Chimica Acta","volume":null,"pages":null},"PeriodicalIF":2.7000,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Azolylphenanthridine-ligated Cu(II) catalyst for electrochemical oxidation of cholesterol in aprotic medium\",\"authors\":\"\",\"doi\":\"10.1016/j.ica.2024.122305\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The synthesis of original 6-(azol-1-yl)phenanthridine ligands and a copper(II) complex based on them is reported. Comprehensive studies of the structural, physicochemical, and electrocatalytic properties for the selected 6-(1<em>H</em>-pyrazol-1-yl)phenanthridine-containing coordination compound have been carried out. The latter has demonstrated pronounced electrochemical and electrocatalytic activities in the enzyme-free cholesterol oxidation in DMSO. A six-stage mechanism including electrocatalytic reduction of cholesterol and subsequent oxidation of its reduction products has been proposed and underpinned by quantum mechanical considerations. Obtained analytical characteristics of the enzyme-free cholesterol oxidation (LoD 0.0032 mM, detectable concentrations 0.01–0.40 mM) open a prospect towards the investigated complexes to be applied as sensitive elements of portable electrochemical platforms for the point-of-care diagnostics.</p></div>\",\"PeriodicalId\":13599,\"journal\":{\"name\":\"Inorganica Chimica Acta\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2024-08-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Inorganica Chimica Acta\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0020169324003967\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, INORGANIC & NUCLEAR\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Inorganica Chimica Acta","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0020169324003967","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, INORGANIC & NUCLEAR","Score":null,"Total":0}
Azolylphenanthridine-ligated Cu(II) catalyst for electrochemical oxidation of cholesterol in aprotic medium
The synthesis of original 6-(azol-1-yl)phenanthridine ligands and a copper(II) complex based on them is reported. Comprehensive studies of the structural, physicochemical, and electrocatalytic properties for the selected 6-(1H-pyrazol-1-yl)phenanthridine-containing coordination compound have been carried out. The latter has demonstrated pronounced electrochemical and electrocatalytic activities in the enzyme-free cholesterol oxidation in DMSO. A six-stage mechanism including electrocatalytic reduction of cholesterol and subsequent oxidation of its reduction products has been proposed and underpinned by quantum mechanical considerations. Obtained analytical characteristics of the enzyme-free cholesterol oxidation (LoD 0.0032 mM, detectable concentrations 0.01–0.40 mM) open a prospect towards the investigated complexes to be applied as sensitive elements of portable electrochemical platforms for the point-of-care diagnostics.
期刊介绍：
Inorganica Chimica Acta is an established international forum for all aspects of advanced Inorganic Chemistry. Original papers of high scientific level and interest are published in the form of Articles and Reviews.
Topics covered include:
• chemistry of the main group elements and the d- and f-block metals, including the synthesis, characterization and reactivity of coordination, organometallic, biomimetic, supramolecular coordination compounds, including associated computational studies;
• synthesis, physico-chemical properties, applications of molecule-based nano-scaled clusters and nanomaterials designed using the principles of coordination chemistry, as well as coordination polymers (CPs), metal-organic frameworks (MOFs), metal-organic polyhedra (MPOs);
• reaction mechanisms and physico-chemical investigations computational studies of metalloenzymes and their models;
• applications of inorganic compounds, metallodrugs and molecule-based materials.
Papers composed primarily of structural reports will typically not be considered for publication.
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