mTOR 信号通路抑制剂可在乳腺癌免疫发病机制中发挥重要作用。

IF 3.3 3区 生物学 Q3 CELL BIOLOGY Cell Biology International Pub Date : 2024-08-20 DOI:10.1002/cbin.12231
Sulieman I. Shelash Al-Hawary, Farag M. A. Altalbawy, Saade Abdalkareem Jasim, Renuka Jyothi S, Azfar Jamal, Mohammed M. Naiyer, Shriya Mahajan, Hitesh Kalra, Mohammed Abed Jawad, Ahmed Hussein Zwamel
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引用次数: 0

摘要

本研究探讨了针对哺乳动物雷帕霉素靶标(mTOR)信号通路的抑制剂在乳腺癌研究和治疗中的关键作用。mTOR 通路是细胞过程的核心调节因子,已被确定为乳腺癌发生和发展的关键因素。文章解释了雷帕霉素及其类似物等 mTOR 抑制剂发挥抗癌作用的复杂分子机制。这些抑制剂可通过阻断 mTOR 通路中的关键信号通路,阻止乳腺癌细胞的生长、增殖和存活。此外,文章还讨论了将 mTOR 抑制剂作为一种综合治疗策略的意义。文章强调了将 mTOR 抑制剂与其他治疗方法相结合以提高乳腺癌治疗效果的潜在益处。乳腺癌研究的不断发展突显了 mTOR 作为治疗靶点的重要性,并强调了目前为改进和优化 mTOR 抑制剂以用于临床所做的努力。总之,文章认为,mTOR 信号通路抑制剂为抗击乳腺癌提供了一种前景广阔的方法。这些抑制剂针对 mTOR 通路中的特定失调提供了有针对性的有效干预。随着研究的深入,将 mTOR 抑制剂整合到定制的综合疗法中,有望为乳腺癌的治疗提供更有效、更个性化的方法,最终改善这种复杂多样疾病患者的治疗效果。
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Inhibitors of the mTOR signaling pathway can play an important role in breast cancer immunopathogenesis

This study explores the critical role of inhibitors targeting the mammalian target of rapamycin (mTOR) signaling pathway in breast cancer research and treatment. The mTOR pathway, a central regulator of cellular processes, has been identified as a crucial factor in the development and progression of breast cancer. The essay explains the complex molecular mechanisms through which mTOR inhibitors, such as rapamycin and its analogs, exert their anticancer effects. These inhibitors can stop cell growth, proliferation, and survival in breast cancer cells by blocking critical signaling pathways within the mTOR pathway. Furthermore, the essay discusses the implications of using mTOR inhibitors as a comprehensive therapeutic strategy. It emphasizes the potential benefits of combining mTOR inhibitors with other treatment approaches to enhance the effectiveness of breast cancer treatment. The evolving landscape of breast cancer research underscores the significance of mTOR as a therapeutic target and highlights ongoing efforts to improve and optimize mTOR inhibitors for clinical use. In conclusion, the essay asserts that inhibitors of the mTOR signaling pathway offer a promising approach in the fight against breast cancer. These inhibitors provide a focused and effective intervention targeting specific dysregulations within the mTOR pathway. As research advances, the integration of mTOR inhibitors into customized combination therapies holds excellent potential for shaping a more effective and personalized approach to breast cancer treatment, ultimately leading to improved outcomes for individuals affected by this complex and diverse disease.

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来源期刊
Cell Biology International
Cell Biology International 生物-细胞生物学
CiteScore
7.60
自引率
0.00%
发文量
208
审稿时长
1 months
期刊介绍: Each month, the journal publishes easy-to-assimilate, up-to-the minute reports of experimental findings by researchers using a wide range of the latest techniques. Promoting the aims of cell biologists worldwide, papers reporting on structure and function - especially where they relate to the physiology of the whole cell - are strongly encouraged. Molecular biology is welcome, as long as articles report findings that are seen in the wider context of cell biology. In covering all areas of the cell, the journal is both appealing and accessible to a broad audience. Authors whose papers do not appeal to cell biologists in general because their topic is too specialized (e.g. infectious microbes, protozoology) are recommended to send them to more relevant journals. Papers reporting whole animal studies or work more suited to a medical journal, e.g. histopathological studies or clinical immunology, are unlikely to be accepted, unless they are fully focused on some important cellular aspect. These last remarks extend particularly to papers on cancer. Unless firmly based on some deeper cellular or molecular biological principle, papers that are highly specialized in this field, with limited appeal to cell biologists at large, should be directed towards journals devoted to cancer, there being very many from which to choose.
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