加权单步全基因组关联研究揭示韩国陆地猪生产性状的新候选基因

IF 2.7 3区 农林科学 Q1 AGRICULTURE, DAIRY & ANIMAL SCIENCE Journal of Animal Science and Technology Pub Date : 2024-07-01 Epub Date: 2024-07-31 DOI:10.5187/jast.2024.e104
Jun Park, Chong-Sam Na
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引用次数: 0

摘要

本研究的目的是利用从兰德瑞斯(Landrace)的五个祖代种猪场(GGP)获得的 37,099 份生产记录和 6,683 个单核苷酸多态性(SNP)数据,鉴定与生产性状相关的基因组区域和候选基因。105公斤日龄(AGE)、平均日增重(ADG)、背膘厚度(BF)和眼肌面积(EMA)的遗传力估计值分别为0.49、0.49、0.56和0.23。我们确定了一个遗传窗口,该窗口对每个性状的总遗传变异的解释率为 2.05%-2.34%。我们观察到四个性状明显分为两组,AGE和ADG最显著的基因组区域位于Sus scrofa染色体(SSC)1上,而BF和EMA则位于SSC 2上。我们对基因本体论(GO)和京都基因组百科全书(KEGG)进行了研究,结果显示了3个生物过程、4个细胞组分、3个分子功能和6个KEGG通路。重要的SNPs可作为标记用于陆地猪生产性状的数量性状位点(QTL)调查和基因组选择(GS)。
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Weighted single-step genome-wide association study to reveal new candidate genes for productive traits of Landrace pig in Korea.

The objective of this study was to identify genomic regions and candidate genes associated with productive traits using a total of 37,099 productive records and 6,683 single nucleotide polymorphism (SNP) data obtained from five Great-Grand-Parents (GGP) farms in Landrace. The estimated of heritabilities for days to 105 kg (AGE), average daily gain (ADG), backfat thickness (BF), and eye muscle area (EMA) were 0.49, 0.49, 0.56, and 0.23, respectively. We identified a genetic window that explained 2.05%-2.34% for each trait of the total genetic variance. We observed a clear partitioning of the four traits into two groups, and the most significant genomic region for AGE and ADG were located on the Sus scrofa chromosome (SSC) 1, while BF and EMA were located on SSC 2. We conducted Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG), which revealed results in three biological processes, four cellular component, three molecular function, and six KEGG pathway. Significant SNPs can be used as markers for quantitative trait loci (QTL) investigation and genomic selection (GS) for productive traits in Landrace pig.

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来源期刊
Journal of Animal Science and Technology
Journal of Animal Science and Technology Agricultural and Biological Sciences-Food Science
CiteScore
4.50
自引率
8.70%
发文量
96
审稿时长
7 weeks
期刊介绍: Journal of Animal Science and Technology (J. Anim. Sci. Technol. or JAST) is a peer-reviewed, open access journal publishing original research, review articles and notes in all fields of animal science. Topics covered by the journal include: genetics and breeding, physiology, nutrition of monogastric animals, nutrition of ruminants, animal products (milk, meat, eggs and their by-products) and their processing, grasslands and roughages, livestock environment, animal biotechnology, animal behavior and welfare. Articles generally report research involving beef cattle, dairy cattle, pigs, companion animals, goats, horses, and sheep. However, studies involving other farm animals, aquatic and wildlife species, and laboratory animal species that address fundamental questions related to livestock and companion animal biology will also be considered for publication. The Journal of Animal Science and Technology (J. Anim. Technol. or JAST) has been the official journal of The Korean Society of Animal Science and Technology (KSAST) since 2000, formerly known as The Korean Journal of Animal Sciences (launched in 1956).
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