淋巴高速公路:淋巴管如何驱动肺部健康与疾病》(The Lymphatic Highway: How Lymphatics Drive Lung Health and Disease.

IF 4.6 2区 医学 Q1 RESPIRATORY SYSTEM Lung Pub Date : 2024-10-01 Epub Date: 2024-08-20 DOI:10.1007/s00408-024-00739-6
Xinyu Zhang, Xinqian Du, Ye Cui
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引用次数: 0

摘要

肺淋巴系统已成为肺稳态的重要调节器和呼吸系统疾病发病机制的关键因素。淋巴管是维持体液平衡和促进免疫细胞运输的主要通道,其完整性对维护正常的肺部结构和功能至关重要。淋巴管异常表现在多种肺部疾病中,突出了淋巴管在呼吸系统健康和疾病中的重要性。本综述概述了肺淋巴生物学,并深入探讨了淋巴管参与四种主要肺部疾病的情况:慢性阻塞性肺疾病(COPD)、特发性肺纤维化(IPF)、哮喘和肺移植排斥反应。我们研究了淋巴异常在上述每种疾病中的表现,并探讨了淋巴重塑和功能障碍导致疾病进展的机制。此外,我们还探讨了针对淋巴系统的治疗潜力,以改善这些使人衰弱的呼吸系统疾病。尽管有了现有的知识,但一些关键问题仍未得到解答,如淋巴变化的时空动态、淋巴管与肺部微环境之间的分子串扰,以及淋巴表型的保护性与有害性之间的区别。揭开这些谜团有望发现新的分子调控因子、淋巴内皮表型特征以及生物活性介质。利用这些知识,我们就能为开发针对肺部疾病淋巴通道的创新疾病调节疗法铺平道路。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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The Lymphatic Highway: How Lymphatics Drive Lung Health and Disease.

The pulmonary lymphatic system has emerged as a critical regulator of lung homeostasis and a key contributor to the pathogenesis of respiratory diseases. As the primary conduit responsible for maintaining fluid balance and facilitating immune cell trafficking, the integrity of lymphatic vessels is essential for preserving normal pulmonary structure and function. Lymphatic abnormalities manifest across a broad spectrum of pulmonary disorders, underscoring their significance in respiratory health and disease. This review provides an overview of pulmonary lymphatic biology and delves into the involvement of lymphatics in four major lung diseases: chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), asthma, and lung transplant rejection. We examine how lymphatic abnormalities manifest in each of these conditions and investigate the mechanisms through which lymphatic remodeling and dysfunction contribute to disease progression. Furthermore, we explore the therapeutic potential of targeting the lymphatic system to ameliorate these debilitating respiratory conditions. Despite the current knowledge, several crucial questions remain unanswered, such as the spatial and temporal dynamics of lymphatic changes, the molecular crosstalk between lymphatics and the lung microenvironment, and the distinction between protective versus detrimental lymphatic phenotypes. Unraveling these mysteries holds the promise of identifying novel molecular regulators, characterizing lymphatic endothelial phenotypes, and uncovering bioactive mediators. By harnessing this knowledge, we can pave the way for the development of innovative disease-modifying therapies targeting the lymphatic highway in lung disorders.

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来源期刊
Lung
Lung 医学-呼吸系统
CiteScore
9.10
自引率
10.00%
发文量
95
审稿时长
6-12 weeks
期刊介绍: Lung publishes original articles, reviews and editorials on all aspects of the healthy and diseased lungs, of the airways, and of breathing. Epidemiological, clinical, pathophysiological, biochemical, and pharmacological studies fall within the scope of the journal. Case reports, short communications and technical notes can be accepted if they are of particular interest.
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