{"title":"自我抗原表达控制中的平衡行为","authors":"Michael R. Waterfield, Mark S. Anderson","doi":"10.1038/s41590-024-01940-8","DOIUrl":null,"url":null,"abstract":"The AIRE protein drives the expression of tissue-restricted self-antigens, required to induce immune tolerance for self-proteins. New work shows the importance of an external interaction between AIRE and the transcriptional activator CBP/p300, and an internal competition for nuclear-condensate formation.","PeriodicalId":19032,"journal":{"name":"Nature Immunology","volume":null,"pages":null},"PeriodicalIF":27.7000,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A balancing act in the control of self-antigen expression\",\"authors\":\"Michael R. Waterfield, Mark S. Anderson\",\"doi\":\"10.1038/s41590-024-01940-8\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The AIRE protein drives the expression of tissue-restricted self-antigens, required to induce immune tolerance for self-proteins. New work shows the importance of an external interaction between AIRE and the transcriptional activator CBP/p300, and an internal competition for nuclear-condensate formation.\",\"PeriodicalId\":19032,\"journal\":{\"name\":\"Nature Immunology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":27.7000,\"publicationDate\":\"2024-08-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature Immunology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.nature.com/articles/s41590-024-01940-8\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"IMMUNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Immunology","FirstCategoryId":"3","ListUrlMain":"https://www.nature.com/articles/s41590-024-01940-8","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
A balancing act in the control of self-antigen expression
The AIRE protein drives the expression of tissue-restricted self-antigens, required to induce immune tolerance for self-proteins. New work shows the importance of an external interaction between AIRE and the transcriptional activator CBP/p300, and an internal competition for nuclear-condensate formation.
期刊介绍:
Nature Immunology is a monthly journal that publishes the highest quality research in all areas of immunology. The editorial decisions are made by a team of full-time professional editors. The journal prioritizes work that provides translational and/or fundamental insight into the workings of the immune system. It covers a wide range of topics including innate immunity and inflammation, development, immune receptors, signaling and apoptosis, antigen presentation, gene regulation and recombination, cellular and systemic immunity, vaccines, immune tolerance, autoimmunity, tumor immunology, and microbial immunopathology. In addition to publishing significant original research, Nature Immunology also includes comments, News and Views, research highlights, matters arising from readers, and reviews of the literature. The journal serves as a major conduit of top-quality information for the immunology community.