Rachel Sintes, Paul McLellan, Gabriele Navelli, Cécilia Landman, Sandrine Delage, Sandrine Truong, Nicolas Benech, Nathalie Kapel, Alicia Moreino Sabater, Aurélie Schnuriger, Catherine Eckert, Alexandre Bleibtreu, Anne-Christine Joly, Harry Sokol
{"title":"使用冷冻的本地粪便进行粪便微生物群移植治疗复发性艰难梭菌感染：提高供体粪便制备效率的简单方法。","authors":"Rachel Sintes, Paul McLellan, Gabriele Navelli, Cécilia Landman, Sandrine Delage, Sandrine Truong, Nicolas Benech, Nathalie Kapel, Alicia Moreino Sabater, Aurélie Schnuriger, Catherine Eckert, Alexandre Bleibtreu, Anne-Christine Joly, Harry Sokol","doi":"10.1128/aac.00734-24","DOIUrl":null,"url":null,"abstract":"<p><p>Preparing fecal microbiota transplants immediately after donation is resource-intensive, and a proportion are destroyed following abnormal screening results. We retrospectively compared two processes, frozen fecal preparation (FFP) and fresh native frozen preparation (FNFP), for clinical efficacy in the treatment of recurrent <i>Clostridioides difficile</i> infection (rCDI). FFP and FNFP were similarly effective with clinical success rates of 76.7% and 86.7% (<i>P</i> = 0.32), respectively. FNFP is an efficient procedure that saves resources while maintaining clinical efficacy in rCDI.</p>","PeriodicalId":8152,"journal":{"name":"Antimicrobial Agents and Chemotherapy","volume":null,"pages":null},"PeriodicalIF":4.1000,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Use of frozen native feces for fecal microbiota transplantation in recurrent <i>Clostridioides difficile</i> infection: a simple way to improve the efficiency of donor feces preparation.\",\"authors\":\"Rachel Sintes, Paul McLellan, Gabriele Navelli, Cécilia Landman, Sandrine Delage, Sandrine Truong, Nicolas Benech, Nathalie Kapel, Alicia Moreino Sabater, Aurélie Schnuriger, Catherine Eckert, Alexandre Bleibtreu, Anne-Christine Joly, Harry Sokol\",\"doi\":\"10.1128/aac.00734-24\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Preparing fecal microbiota transplants immediately after donation is resource-intensive, and a proportion are destroyed following abnormal screening results. We retrospectively compared two processes, frozen fecal preparation (FFP) and fresh native frozen preparation (FNFP), for clinical efficacy in the treatment of recurrent <i>Clostridioides difficile</i> infection (rCDI). FFP and FNFP were similarly effective with clinical success rates of 76.7% and 86.7% (<i>P</i> = 0.32), respectively. FNFP is an efficient procedure that saves resources while maintaining clinical efficacy in rCDI.</p>\",\"PeriodicalId\":8152,\"journal\":{\"name\":\"Antimicrobial Agents and Chemotherapy\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.1000,\"publicationDate\":\"2024-08-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Antimicrobial Agents and Chemotherapy\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1128/aac.00734-24\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MICROBIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Antimicrobial Agents and Chemotherapy","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1128/aac.00734-24","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MICROBIOLOGY","Score":null,"Total":0}
Use of frozen native feces for fecal microbiota transplantation in recurrent Clostridioides difficile infection: a simple way to improve the efficiency of donor feces preparation.
Preparing fecal microbiota transplants immediately after donation is resource-intensive, and a proportion are destroyed following abnormal screening results. We retrospectively compared two processes, frozen fecal preparation (FFP) and fresh native frozen preparation (FNFP), for clinical efficacy in the treatment of recurrent Clostridioides difficile infection (rCDI). FFP and FNFP were similarly effective with clinical success rates of 76.7% and 86.7% (P = 0.32), respectively. FNFP is an efficient procedure that saves resources while maintaining clinical efficacy in rCDI.
期刊介绍：
Antimicrobial Agents and Chemotherapy (AAC) features interdisciplinary studies that build our understanding of the underlying mechanisms and therapeutic applications of antimicrobial and antiparasitic agents and chemotherapy.
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