多囊卵巢综合征与绝经前和绝经后妇女罹患乳腺癌的风险:一项全国性人群队列研究。

IF 3 3区 医学 Q2 ONCOLOGY Breast Cancer Research and Treatment Pub Date : 2024-12-01 Epub Date: 2024-08-21 DOI:10.1007/s10549-024-07467-8
Clarissa L B Frandsen, Bugge Nøhr, Mathilde Gottschau, Jakob H Viuff, Thomas Maltesen, Susanne K Kjær, Pernille F Svendsen, Allan Jensen
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引用次数: 0

摘要

目的:虽然多囊卵巢综合征(PCOS)的一些生殖和代谢特征是乳腺癌的已知风险因素,但有关 PCOS 与乳腺癌之间潜在联系的证据却很少。在这项基于人群的队列研究中,我们调查了多囊卵巢综合征与乳腺癌之间的关系:PCOS 诊断、癌症诊断、协变量、迁移和生命状态均来自全国人口和健康登记。结果:在 26 年的中位随访期间,PCOS 与乳腺癌的关系发生了显著变化:在 26 年的中位随访期间,共有 63078 名妇女被诊断出患有乳腺癌。我们发现,与未患多囊卵巢综合征的女性相比,患有多囊卵巢综合征的女性罹患乳腺癌的风险总体上有所增加(HR:1.21,95% CI 1.02-1.44)。在根据绝经状况进行的分层分析中,风险增加仅限于绝经后妇女(HR:1.63,95% CI 1.23-2.15)。对导管和小叶组织学亚型的单独分析结果与对乳腺癌总体情况的分析结果相似:这是首个报告有多囊卵巢综合症病史的女性罹患乳腺癌风险增加的研究。结论:这是第一份关于有多囊卵巢综合症病史的女性患乳腺癌风险增加的研究报告,增加的风险似乎仅限于绝经后女性。因此,我们的研究结果有助于增加人们对乳腺癌病因的了解,但我们的研究结果应在其他大型队列研究中得到进一步证实,并进行适当的长期随访。
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Polycystic ovary syndrome and risk of breast cancer in premenopausal and postmenopausal women: a nationwide population-based cohort study.

Purpose: Although some reproductive and metabolic characteristics of polycystic ovary syndrome (PCOS) are known risk factors for breast cancer, the evidence regarding a potential association between PCOS and breast cancer is scarce. In this population-based cohort study including all 1,719,452 women born in Denmark between 1940 and 1993, we investigated the association between PCOS and breast cancer.

Methods: PCOS diagnoses, cancer diagnoses, covariates, migrations, and vital status were all obtained from national population and health registers. Hazard ratios (HR) and 95% confidence intervals (CI) for breast cancer overall and for histological subtypes separately were calculated based on adjusted cox proportional hazards models.

Results: During a median follow-up of 26 years, 63,078 women were diagnosed with breast cancer. We found an increased risk of breast cancer overall among women with PCOS compared with women without PCOS (HR: 1.21, 95% CI 1.02-1.44). In analyses stratified for menopausal status, the increased risk was restricted to postmenopausal women (HR: 1.63, 95% CI 1.23-2.15). The results for ductal and lobular histological subtypes analyses separately resembled those observed for breast cancer overall.

Conclusion: This is the first study to report an increased risk of breast cancer among women with a history of PCOS. The increased risk was seemingly confined to postmenopausal women. Our results therefore contribute to an increased knowledge of the etiology of breast cancer, but our findings should be further confirmed in other large cohort studies with an appropriately long follow-up period.

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来源期刊
CiteScore
6.80
自引率
2.60%
发文量
342
审稿时长
1 months
期刊介绍: Breast Cancer Research and Treatment provides the surgeon, radiotherapist, medical oncologist, endocrinologist, epidemiologist, immunologist or cell biologist investigating problems in breast cancer a single forum for communication. The journal creates a "market place" for breast cancer topics which cuts across all the usual lines of disciplines, providing a site for presenting pertinent investigations, and for discussing critical questions relevant to the entire field. It seeks to develop a new focus and new perspectives for all those concerned with breast cancer.
期刊最新文献
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