LPS 相关女性生育能力下降的潜在机制和治疗策略。

IF 3.2 3区医学 Q2 GENETICS & HEREDITY Journal of Assisted Reproduction and Genetics Pub Date : 2024-10-01 Epub Date: 2024-08-21 DOI:10.1007/s10815-024-03226-2

Xue Qin, Junhong Du, Ruifen He, Yaxi Li, Hongli Li, Xiaolei Liang

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引用次数: 0

摘要

作为革兰氏阴性细菌外膜的主要成分，脂多糖（LPS）可被收费样受体（TLR）识别，并通过MyD88或含TIR结构域的适配器诱导干扰素-β（TRIF）途径诱发炎症。以往的研究发现，LPS 相关的炎症/免疫挑战与卵巢功能障碍和女性生育能力下降有关。然而，目前与 LPS 相关的女性生育力下降的病因和发病机制是复杂和多方面的。本综述使用 PubMed 搜索有关 LPS 和生育力下降的参考文献，以阐明 LPS 相关女性生育力下降的潜在机制，并总结可能改善 LPS 相关生育力下降的治疗策略。

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Potential mechanisms and therapeutic strategies for LPS-associated female fertility decline.

As a major component of the outer membrane of Gram-negative bacteria, lipopolysaccharide (LPS) can be recognized by toll-like receptors (TLRs) and induce inflammation through MyD88 or the TIR domain-containing adapter-inducing interferon-β (TRIF) pathway. Previous studies have found that LPS-associated inflammatory/immune challenges were associated with ovarian dysfunction and reduced female fertility. However, the etiology and pathogenesis of female fertility decline associated with LPS are currently complex and multifaceted. In this review, PubMed was used to search for references on LPS and fertility decline so as to elucidate the potential mechanisms of LPS-associated female fertility decline and summarize therapeutic strategies that may improve LPS-associated fertility decline.

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来源期刊

Journal of Assisted Reproduction and Genetics 医学-妇产科学

CiteScore

5.70

自引率

9.70%

发文量

286

审稿时长

1 months

期刊介绍： The Journal of Assisted Reproduction and Genetics publishes cellular, molecular, genetic, and epigenetic discoveries advancing our understanding of the biology and underlying mechanisms from gametogenesis to offspring health. Special emphasis is placed on the practice and evolution of assisted reproduction technologies (ARTs) with reference to the diagnosis and management of diseases affecting fertility. Our goal is to educate our readership in the translation of basic and clinical discoveries made from human or relevant animal models to the safe and efficacious practice of human ARTs. The scientific rigor and ethical standards embraced by the JARG editorial team ensures a broad international base of expertise guiding the marriage of contemporary clinical research paradigms with basic science discovery. JARG publishes original papers, minireviews, case reports, and opinion pieces often combined into special topic issues that will educate clinicians and scientists with interests in the mechanisms of human development that bear on the treatment of infertility and emerging innovations in human ARTs. The guiding principles of male and female reproductive health impacting pre- and post-conceptional viability and developmental potential are emphasized within the purview of human reproductive health in current and future generations of our species. The journal is published in cooperation with the American Society for Reproductive Medicine, an organization of more than 8,000 physicians, researchers, nurses, technicians and other professionals dedicated to advancing knowledge and expertise in reproductive biology.