胸腺选择对 TCR 基因库的划分。

IF 12.6 1区 医学 Q1 IMMUNOLOGY Journal of Experimental Medicine Pub Date : 2024-10-07 Epub Date: 2024-08-21 DOI:10.1084/jem.20230897
Wan-Lin Lo, Eric S Huseby
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引用次数: 0

摘要

αβ T 细胞是适应性免疫系统的关键组成部分;它们在健康期间维持组织和免疫平衡,在病原体感染后提供杀菌免疫,并能消除转化的肿瘤细胞。这些不同功能的基础是每个成熟 T 细胞(TCR)上表达的独特抗原受体的配体特异性,这种特异性赋予淋巴细胞以细胞自主、疾病特异性的行为方式。当胸腺细胞利用 TCR 识别主要组织相容性复合体(MHC)和类似 MHC 的配体来决定存亡,并分化成大量炎性和调节性 T 细胞系时,克隆特异性行为特性就在 T 细胞发育过程中初步建立起来了。在这里,我们回顾了预选胸腺细胞谱系的配体特异性,并认为 TCR 信号传导的发育阶段特异性改变控制着 T 细胞亚系的交叉反应和外来与自身特异性。
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The partitioning of TCR repertoires by thymic selection.

αβ T cells are critical components of the adaptive immune system; they maintain tissue and immune homeostasis during health, provide sterilizing immunity after pathogen infection, and are capable of eliminating transformed tumor cells. Fundamental to these distinct functions is the ligand specificity of the unique antigen receptor expressed on each mature T cell (TCR), which endows lymphocytes with the ability to behave in a cell-autonomous, disease context-specific manner. Clone-specific behavioral properties are initially established during T cell development when thymocytes use TCR recognition of major histocompatibility complex (MHC) and MHC-like ligands to instruct survival versus death and to differentiate into a plethora of inflammatory and regulatory T cell lineages. Here, we review the ligand specificity of the preselection thymocyte repertoire and argue that developmental stage-specific alterations in TCR signaling control cross-reactivity and foreign versus self-specificity of T cell sublineages.

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来源期刊
CiteScore
26.60
自引率
1.30%
发文量
189
审稿时长
3-8 weeks
期刊介绍: Since its establishment in 1896, the Journal of Experimental Medicine (JEM) has steadfastly pursued the publication of enduring and exceptional studies in medical biology. In an era where numerous publishing groups are introducing specialized journals, we recognize the importance of offering a distinguished platform for studies that seamlessly integrate various disciplines within the pathogenesis field. Our unique editorial system, driven by a commitment to exceptional author service, involves two collaborative groups of editors: professional editors with robust scientific backgrounds and full-time practicing scientists. Each paper undergoes evaluation by at least one editor from both groups before external review. Weekly editorial meetings facilitate comprehensive discussions on papers, incorporating external referee comments, and ensure swift decisions without unnecessary demands for extensive revisions. Encompassing human studies and diverse in vivo experimental models of human disease, our focus within medical biology spans genetics, inflammation, immunity, infectious disease, cancer, vascular biology, metabolic disorders, neuroscience, and stem cell biology. We eagerly welcome reports ranging from atomic-level analyses to clinical interventions that unveil new mechanistic insights.
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