[德国耳鼻喉科研究中心 "口咽癌 "多中心登记 - 初步结果]。

IF 0.9 4区 医学 Q3 OTORHINOLARYNGOLOGY Laryngo-rhino-otologie Pub Date : 2024-08-21 DOI:10.1055/a-2374-2310
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引用次数: 0

摘要

背景:近年来,由人类乳头瘤病毒(HPV)引起的口咽鳞状细胞癌(OPSCC)数量大幅增加。然而,关于中欧地区与人乳头瘤病毒相关的口咽鳞状细胞癌的发病率及其治疗情况,目前还没有可靠的数据:工作目的:旨在建立中欧 OPSCC 患者的流行病学登记册:为了填补 p16 阳性 OPSCC 的证据空白,我们在德国癌症协会认证的头颈部肿瘤中心建立了一个前瞻性多中心登记处,登记 OPSCC 的发病率、风险因素和治疗方法。数据收集采用网络研究电子数据采集(REDCap)的匿名方式进行:结果:2022年和2023年,来自34个中心的1312名OPSCC患者被纳入研究。720名患者(58.2%)p16阳性。p16阳性原发肿瘤最常见的部位是扁桃体(49.9%)和舌根部(28.7%)。63.1%的 p16 阳性 OPSCC 接受了原发手术治疗,而只有 48.0% 的 p16 阴性肿瘤接受了原发手术治疗。辅助治疗方面的差异也很明显:58%的p16阴性OPSCC在术后没有接受辅助治疗,而p16阳性OPSCC的这一比例为37.1%:OPSCC登记研究的启动在技术上十分顺利。结论:OPSCC登记研究的启动在技术上非常顺利,该登记研究有助于了解德语国家OPSCC的治疗现状,随着更多中心的参与,该登记研究的重要性将进一步提高。
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[The multicenter registry "oropharyngeal cancer" of the German ENT Study Center - First Results].

Background:  The number of oropharyngeal squamous cell carcinomas (OPSCC) caused by human papillomavirus (HPV) has increased significantly in recent years. However, no robust data exist on the incidence of HPV-associated OPSCC as well as their treatment in central Europe.

Aim of the work:  The aim is to establish an epidemiological register of patients with OPSCC in central Europe.

Material and methods:  To close the evidence gap on p16-positive OPSCC, a prospective multicenter registry on incidence, risk factors and treatment of OPSCC in certified Head and Neck Tumor Centers according to the German Cancer Society was established. Data collection was pseudonymously performed using the web-based Research Electronic Data Capture (REDCap).

Results:  In 2022 and 2023, 1312 patients with OPSCC from 34 centers were included. 720 patients (58.2 %) were p16-positive. The most common locations of p16-positive primary tumors were the tonsil (49.9 %) and the base of the tongue (28.7 %). 63.1 % of p16-positive OPSCC received primary surgical treatment, whereas only 48.0 % of p16-negative tumors received primary surgery. Differences are also evident in the adjuvant therapy: 58 % of p16-negative OPSCC did not receive adjuvant therapy after surgery, compared with 37.1 % of p16-positive OPSCC.

Conclusion:  The start of the OPSCC registry study was technically smooth. This registry provides an insight into the current care situation of OPSCC in German-speaking countries and will gain importance through the participation of more centers.

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来源期刊
Laryngo-rhino-otologie
Laryngo-rhino-otologie 医学-耳鼻喉科学
CiteScore
1.00
自引率
30.00%
发文量
1399
审稿时长
6-12 weeks
期刊介绍: Die Laryngo-Rhino-Otologie ist die deutschsprachige Fachzeitschrift für Ärzte in Klinik und Praxis mit Fokus auf die Hals-Nasen-Ohren-Heilkunde, Kopf- und Halschirurgie. Die Laryngo-Rhino-Otologie bringt die Themen, die Sie wirklich interessieren und in der täglichen Arbeit unterstützen: Kurze, leicht lesbare Beiträge, interessante Rubriken und Originalarbeiten mit Relevanz für Ihre Arbeit.
期刊最新文献
[(Exercise) Inducible Laryngeal Obstruction: What to do in the attack, what to do to avoid another one?] [An atypical medial canthal mass: a case of lacrimal sac inverted papilloma with literature review]. [Larynx Models in Voice Research and their Applications]. [Sinunasal surgery as outpatient procedure with special consideration of nasal packing - Position paper of the German Society of Otorhinolaryngology, Head and Neck Surgery, the working group Rhinology/Rhinosurgery (ARHIN) of the German Society of Otorhinolaryngology, Head and Neck Surgery and German Professional Association of Otorhinolaryngologists]. [Survey on the use of nasal tamponades in sinunasal surgery].
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