改良应激性高血糖率对糖尿病患者孤立冠状动脉搭桥手术后早期肺炎的预测作用。

0 MEDICINE, RESEARCH & EXPERIMENTAL Biomolecules & biomedicine Pub Date : 2025-01-14 DOI:10.17305/bb.2024.10330
Ahmet Kağan As, Mesut Engin
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引用次数: 0

摘要

术后肺炎(PP)是冠状动脉旁路移植(CABG)手术后最严重的并发症之一。最近开发的入院血糖(ABG)/估计平均血糖(eAG)比值已被确定为心血管疾病的预后标志物。本研究旨在探讨改良 ABG/eAG (mABG/eAG) 比值对接受 CABG 手术的糖尿病患者术后早期肺炎发生的预测作用。在这项单中心研究中,纳入了2018年1月1日至2023年1月1日期间在训练研究医院接受孤立冠状动脉搭桥手术的糖尿病患者。未发生 PP 的患者被分配到对照组,而发生 PP 的患者被分配到 PP 组。研究共纳入了549名患者,其中对照组478名(中位年龄=58岁[35-81岁]),PP组71名(中位年龄=63岁[37-86岁])。在多变量分析中,使用包装血制品(几率比[OR] = 1.685,95% 置信区间[CI]:1.453 -1.8P = 0.027)、mABG/eAG 比值(OR = 1.659,95% 置信区间 [CI]:1.190 - 2.397;P = 0.019)和再次插管(OR = 1.829,95% 置信区间 [CI]:1.656 - 1.945;P = 0.034)被确定为 PP 发生的独立预测因素。我们的研究结果表明,在接受 CABG 手术的糖尿病患者中,mABG/eAG 比值是 PP 的独立预测因子。根据我们的研究结果,可以通过计算 mABG/eAG 比值来识别高危患者。
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The predictive role of modified stress hyperglycemia rate in predicting early pneumonia after isolated coronary bypass surgery in patients with diabetes mellitus.

Postoperative pneumonia (PP) is one of the most serious complications following coronary artery bypass graft (CABG) surgery. The recently developed admission blood glucose (ABG)/estimated average glucose (eAG) ratio has been identified as a prognostic marker in cardiovascular diseases. This study aimed to investigate the predictive role of the modified ABG/eAG (mABG/eAG) ratio in the development of pneumonia during the early postoperative period in diabetic patients undergoing CABG surgery. In this single-center study, diabetic patients who underwent isolated coronary bypass surgery at the Training and Research Hospital between 1 January 2018 and 1 January 2023 were included. Patients who did not develop PP were assigned to the control group, while those who developed PP were assigned to the PP group. A total of 549 patients were included in the study, 478 patients in the control group (median age = 58 years [range 35-81]) and 71 patients in the PP group (median age = 63 years [37-86]). In the multivariate analysis, the use of packed blood products (odds ratio [OR] = 1.685, 95% confidence interval [CI]: 1.453 - 1.892; P = 0.027), mABG/eAG ratio (OR = 1.659, 95% CI: 1.190 - 2.397; P = 0.019), and re-intubation (OR = 1.829, 95% CI: 1.656 - 1.945; P = 0.034) were identified as independent predictors for the development of PP. Our findings demonstrate that the mABG/eAG ratio is an independent predictor of PP in diabetic patients undergoing CABG surgery. Based on our results, high-risk patients can be identified by calculating the mABG/eAG ratio.

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