HCV相关肝细胞癌的遗传学和表观遗传学文献综述:转化影响。

IF 6.1 2区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Hepatobiliary surgery and nutrition Pub Date : 2024-08-01 Epub Date: 2024-04-18 DOI:10.21037/hbsn-23-562
Ziyan Pan, Wai-Kay Seto, Chun-Jen Liu, Yilei Mao, Saleh A Alqahtani, Mohammed Eslam
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引用次数: 0

摘要

背景和目的:肝细胞癌(HCC)给全球健康造成了巨大负担,在全球癌症发病率中排名第五。丙型肝炎病毒(HCV)感染仍然是导致 HCC 发展的主要风险因素之一。HCC 是一种异质性疾病,由 HCV 引起的 HCC 的发展错综复杂,涉及多种因素,包括遗传易感性、病毒因素、慢性炎症引起的免疫反应、酗酒以及与脂肪肝相关的代谢功能障碍。在这篇综述中,我们全面回顾了与HCV感染相关的HCC发病所涉及的遗传学和表观遗传学机制研究的最新进展。我们还讨论了潜在的转化意义,包括新型生物标记物和治疗药物:2023 年 6 月,我们在 PubMed 和 Embase 数据库中进行了全面的文献检索:最近的研究结果表明,多种遗传和表观遗传过程参与了发病机制,即使在完全清除 HCV 后,这些过程仍然存在。表观基因组的失调已被确定为肝病致死的一个重要因素,尤其是在基因改变并不常见的初期阶段。基因表达的持久 "表观遗传记忆 "被认为是由表观遗传机制调控的,这表明即使在成功治疗后,HCV 感染引起的改变仍然存在,并与肝癌的发病风险有关。需要采用系统生物学分析方法来确定肿瘤演变过程中基因和表观基因组改变的程度和意义:通过促进对这些方面更深入的了解,最终将推动新型疗法的发展,并最终改善患者的预后。
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A literature review of genetics and epigenetics of HCV-related hepatocellular carcinoma: translational impact.

Background and objective: Hepatocellular carcinoma (HCC) poses a significant global health burden and ranks as the fifth most prevalent cancer on a global scale. Hepatitis C virus (HCV) infection remains one of the major risk factors for HCC development. HCC is a heterogeneous disease, and the development of HCC caused by HCV is intricate and involves various factors, including genetic susceptibility, viral factors, immune response due to chronic inflammation, alcohol abuse, and metabolic dysfunction associated with fatty liver disease. In this review, we provide a comprehensive and updated review of research on the genetics and epigenetic mechanisms implicated in developing HCC associated with HCV infection. We also discuss the potential translational implications, including novel biomarkers and drugs for treatment.

Methods: A comprehensive literature search was conducted in June 2023 in PubMed and Embase databases.

Key content and findings: Recent findings indicate that a variety of genetic and epigenetic processes are involved in the pathogenesis and continue to exist even after the complete elimination of HCV. The deregulation of the epigenome has been identified as a significant factor in the deletrious effects of liver disease, especially during the initial stages when genetic alterations are uncommon. The enduring "epigenetic memory" of gene expression is believed to be regulated by epigenetic mechanisms, indicating that alterations caused by HCV infection continue to exist and are linked to the risk of development of liver cancer even after successful treatment. Systems biology analytical methods will be required to delineate the magnitude and significance of both genetic and epigenomic alterations in tumor evolution.

Conclusions: By facilitating a more profound understanding of these aspects, this will ultimately foster the advancement of novel therapies and ultimately improve outcomes for patients.

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来源期刊
自引率
10.00%
发文量
392
期刊介绍: Hepatobiliary Surgery and Nutrition (HBSN) is a bi-monthly, open-access, peer-reviewed journal (Print ISSN: 2304-3881; Online ISSN: 2304-389X) since December 2012. The journal focuses on hepatopancreatobiliary disease and nutrition, aiming to present new findings and deliver up-to-date, practical information on diagnosis, prevention, and clinical investigations. Areas of interest cover surgical techniques, clinical and basic research, transplantation, therapies, NASH, NAFLD, targeted drugs, gut microbiota, metabolism, cancer immunity, genomics, and nutrition and dietetics. HBSN serves as a valuable resource for professionals seeking insights into diverse aspects of hepatobiliary surgery and nutrition.
期刊最新文献
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