通过距离加权稀疏表示估算的感觉和运动皮层细分,并将其应用于自闭症谱系障碍。

IF 5.3 2区 医学 Q1 CLINICAL NEUROLOGY Progress in Neuro-Psychopharmacology & Biological Psychiatry Pub Date : 2024-08-22 DOI:10.1016/j.pnpbp.2024.111125
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引用次数: 0

摘要

背景:自闭症谱系障碍(ASD)患者普遍存在运动障碍和感觉处理异常,这与初级运动皮层(M1)和初级体感皮层(S1)的核心功能密切相关。目前,有关自闭症谱系障碍患者 M1 和 S1 亚区域潜在治疗靶点的知识还很有限。本研究旨在绘制具有临床意义的 M1 和 S1 功能亚区图:静息态功能磁共振成像数据(NTD = 266)来自自闭症脑成像数据交换中心(ABIDE),用于亚区建模。我们提出了一种距离加权稀疏表示算法来构建大脑功能网络。通过在组水平上的共识聚类,确定了 M1 和 S1 的功能亚区。分析了功能亚区特征的差异及其与临床评分的相关性:结果:我们观察到 M1 和 S1 从背侧到腹侧对称且连续的亚区组织,其中 M1 亚区符合运动同源体的功能模式。在 M1 的背侧和腹侧发现了显著的组间差异和临床相关性(p 限制):分段模型的推广性需要进一步评估:本研究强调了 M1 和 S1 在 ASD 治疗中的重要性,并可能为大脑分层和 ASD 治疗目标的确定提供新的见解。
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Sensory and motor cortices parcellations estimated via distance-weighted sparse representation with application to autism spectrum disorder

Background

Motor impairments and sensory processing abnormalities are prevalent in autism spectrum disorder (ASD), closely related to the core functions of the primary motor cortex (M1) and the primary somatosensory cortex (S1). Currently, there is limited knowledge about potential therapeutic targets in the subregions of M1 and S1 in ASD patients. This study aims to map clinically significant functional subregions of M1 and S1.

Methods

Resting-state functional magnetic resonance imaging data (NTD = 266) from Autism Brain Imaging Data Exchange (ABIDE) were used for subregion modeling. We proposed a distance-weighted sparse representation algorithm to construct brain functional networks. Functional subregions of M1 and S1 were identified through consensus clustering at the group level. Differences in the characteristics of functional subregions were analyzed, along with their correlation with clinical scores.

Results

We observed symmetrical and continuous subregion organization from dorsal to ventral aspects in M1 and S1, with M1 subregions conforming to the functional pattern of the motor homunculus. Significant intergroup differences and clinical correlations were found in the dorsal and ventral aspects of M1 (p < 0.05/3, Bonferroni correction) and the ventromedial BA3 of S1 (p < 0.05/5). These functional characteristics were positively correlated with autism severity. All subregions showed significant results in the ROI-to-ROI intergroup differential analysis (p < 0.05/80).

Limitations

The generalizability of the segmentation model requires further evaluation.

Conclusions

This study highlights the significance of M1 and S1 in ASD treatment and may provide new insights into brain parcellation and the identification of therapeutic targets for ASD.

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来源期刊
CiteScore
12.00
自引率
1.80%
发文量
153
审稿时长
56 days
期刊介绍: Progress in Neuro-Psychopharmacology & Biological Psychiatry is an international and multidisciplinary journal which aims to ensure the rapid publication of authoritative reviews and research papers dealing with experimental and clinical aspects of neuro-psychopharmacology and biological psychiatry. Issues of the journal are regularly devoted wholly in or in part to a topical subject. Progress in Neuro-Psychopharmacology & Biological Psychiatry does not publish work on the actions of biological extracts unless the pharmacological active molecular substrate and/or specific receptor binding properties of the extract compounds are elucidated.
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