疗养院使用抗精神病药物的联邦政策对痴呆症住院患者获批适应症新诊断的影响。

Theresa I Shireman, Neto Coulibaly, Tingting Zhang, Andrew R Zullo, Lauren B Gerlach, Antoinette B Coe, Lori A Daiello, Derrick Lo, Julie P W Bynum
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引用次数: 0

摘要

背景:针对疗养院(NH)住院患者使用抗精神病药物的联邦政策可能会增加对精神分裂症、抽动秽语综合征和亨廷顿氏病等已获批准用途的诊断报告(被称为 "排除性诊断",因为它们将住院患者排除在抗精神病药物质量指标之外)。我们评估了在联邦政策出台后,长期住院的 NH 中新的排除性诊断(特别是痴呆症)的变化情况:回顾性、季度性、间断时间序列分析(2009-2018 年),对象为患有痴呆症且在入住 NH 之前未报告排除性诊断的新入住 NH 的长期住院患者。国家合作伙伴关系和五星质量评级系统中增加的设施水平抗精神病药物使用是关键的时间暴露。研究结果是根据疗养院的特征对入院后两年内排除性诊断的季度设施水平预测百分比:结果:在 264 095 例长期住院患者中,伙伴关系实施前新的排他性诊断的平均比例为 2.2%。合作计划实施后,随着时间的推移,该百分比出现了未调整的增长(斜率变化,0.044,p = 0.018),但该百分比从未超过 2.9%。在黑人居民比例处于中等水平的 NHs 中,"伙伴关系 "促使诊断率一次性下降(-1.29%,p = 0.004)。在 "伙伴关系 "之前,非营利性 NHs 的诊断率相对于营利性 NHs 有所上升 (0.044; p = 0.012),但在 "伙伴关系 "之后,这种模式发生了逆转。营利性 NH 增加了(+0.034,p = 0.002);非营利性 NH 减少了(-0.014,p = 0.039)。质量评级修改没有明显影响:患有痴呆症的长期住院疗养院居民是抗精神病药物的高危人群,他们的排除性诊断报告并未因联邦政策而增加。有必要对非痴呆症 NH 居民中排除性诊断增加的原因进行评估,同时继续关注如何激励痴呆症居民合理用药,这对高质量的 NH 护理至关重要。
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Impact of federal antipsychotic use policy in nursing homes on new diagnoses for approved indications in dementia residents.

Background: Federal policies targeting antipsychotic use among nursing home (NH) residents may have increased reporting of diagnoses for approved uses, including schizophrenia, Tourette's syndrome, and Huntington's Disease (called "exclusionary diagnoses" because they exclude residents from the antipsychotic quality metric). We assessed changes in new exclusionary diagnoses among long-stay NH admissions specifically with dementia following federal policies.

Methods: Retrospective, quarterly, interrupted time-series analysis (2009-2018) of new long-stay NH residents with dementia and no exclusionary diagnoses reported before NH admission. The National Partnership and the addition of facility level antipsychotic use to the Five Star Quality Rating system were key time exposures. Outcome was quarterly facility level predicted percentage of exclusionary diagnoses within 2 years of admission stratified by NH characteristics.

Results: For 264,095 long-stay admissions, mean percentage of new exclusionary diagnoses was 2.2% before the Partnership. After the Partnership, there was an unadjusted increase in the percentage over time (slope change, 0.044, p = 0.018), but the percentage never exceeded 2.9%. The Partnership contributed to a one-time decrease in diagnoses in NHs with an intermediate percentage of Black residents (-1.29%, p = 0.004). Before the Partnership, diagnoses were increasing among not-for-profit relative to for-profit NHs (0.044; p = 0.012), but after the Partnership, the pattern reversed. For-profit NHs saw an increase (+0.034, p = 0.002); not-for-profit NHs experienced a decrease (-0.014, p = 0.039). Quality Rating modifications had no significant effect.

Conclusions: Exclusionary diagnosis reporting among long-stay NH residents with dementia, the group most at risk from antipsychotics, did not increase in response to federal policies. Evaluation of reasons for the observed increase in exclusionary diagnoses among non-dementia NH residents is warranted along with continued attention to how to incentivize the appropriate use of medications in residents with dementia that is crucial for high-quality NH care.

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Caring for dementia caregivers: How well does social risk screening reflect unmet needs? End-of-life emergency department use and healthcare expenditures among older adults: A nationally representative study. Antipsychotics for nursing home residents with dementia: Chemical restraints or essential therapeutic intervention? Identifying and quantifying potentially problematic prescribing cascades in clinical practice: A mixed-methods study. Clinical momentum in the care of older adults with advanced dementia: What evidence is there in the medical record?
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