Sonja Steen MD, DDS, Dominik Horn MD, DDS, Christa Flechtenmacher MD, Jürgen Hoffmann MD, DDS, Kolja Freier MD, DDS, Oliver Ristow MD, DDS, Jochen Hess PhD, Julius Moratin MD, DDS
{"title":"口腔鳞状细胞癌患者中 SOX2 和 SOX9 的表达分析。","authors":"Sonja Steen MD, DDS, Dominik Horn MD, DDS, Christa Flechtenmacher MD, Jürgen Hoffmann MD, DDS, Kolja Freier MD, DDS, Oliver Ristow MD, DDS, Jochen Hess PhD, Julius Moratin MD, DDS","doi":"10.1002/hed.27925","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>Lately SOX2 and SOX9, transcription factors associated with stemness-like phenotypes of cancer cells, have been linked to tumor growth, metastasis, and resistance to therapy.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>This study aimed on evaluating the expression of SOX2 and SOX9 in a large cohort of patients with OSCC including primary and recurrent tumors and corresponding lymph node metastases. Semiautomatic digital pathology scoring was used to determine protein expression and survival analysis was performed to evaluate its prognostic significance.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>We found a significant downregulation of SOX9 from primary disease to lymph node metastases (<i>p</i> < 0.001). SOX9 expression and the subgroup SOX2<sup>low</sup>SOX9<sup>high</sup> were significantly correlated with worse overall survival (<i>p</i> < 0.05). Additionally, SOX2<sup>low</sup>SOX9<sup>high</sup> expression pattern was confirmed as independent prognosticator for overall survival.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>These results indicate the relevant role of SOX2 and SOX9 in patients with OSCC and show the clinical relevance for further investigation on the molecular mechanisms underlying SOX-related gene expression.</p>\n </section>\n </div>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":"47 2","pages":"437-451"},"PeriodicalIF":2.2000,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11717967/pdf/","citationCount":"0","resultStr":"{\"title\":\"Expression analysis of SOX2 and SOX9 in patients with oral squamous cell carcinoma\",\"authors\":\"Sonja Steen MD, DDS, Dominik Horn MD, DDS, Christa Flechtenmacher MD, Jürgen Hoffmann MD, DDS, Kolja Freier MD, DDS, Oliver Ristow MD, DDS, Jochen Hess PhD, Julius Moratin MD, DDS\",\"doi\":\"10.1002/hed.27925\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background</h3>\\n \\n <p>Lately SOX2 and SOX9, transcription factors associated with stemness-like phenotypes of cancer cells, have been linked to tumor growth, metastasis, and resistance to therapy.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>This study aimed on evaluating the expression of SOX2 and SOX9 in a large cohort of patients with OSCC including primary and recurrent tumors and corresponding lymph node metastases. Semiautomatic digital pathology scoring was used to determine protein expression and survival analysis was performed to evaluate its prognostic significance.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>We found a significant downregulation of SOX9 from primary disease to lymph node metastases (<i>p</i> < 0.001). SOX9 expression and the subgroup SOX2<sup>low</sup>SOX9<sup>high</sup> were significantly correlated with worse overall survival (<i>p</i> < 0.05). Additionally, SOX2<sup>low</sup>SOX9<sup>high</sup> expression pattern was confirmed as independent prognosticator for overall survival.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusions</h3>\\n \\n <p>These results indicate the relevant role of SOX2 and SOX9 in patients with OSCC and show the clinical relevance for further investigation on the molecular mechanisms underlying SOX-related gene expression.</p>\\n </section>\\n </div>\",\"PeriodicalId\":55072,\"journal\":{\"name\":\"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck\",\"volume\":\"47 2\",\"pages\":\"437-451\"},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2024-08-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11717967/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/hed.27925\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"OTORHINOLARYNGOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/hed.27925","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"OTORHINOLARYNGOLOGY","Score":null,"Total":0}
Expression analysis of SOX2 and SOX9 in patients with oral squamous cell carcinoma
Background
Lately SOX2 and SOX9, transcription factors associated with stemness-like phenotypes of cancer cells, have been linked to tumor growth, metastasis, and resistance to therapy.
Methods
This study aimed on evaluating the expression of SOX2 and SOX9 in a large cohort of patients with OSCC including primary and recurrent tumors and corresponding lymph node metastases. Semiautomatic digital pathology scoring was used to determine protein expression and survival analysis was performed to evaluate its prognostic significance.
Results
We found a significant downregulation of SOX9 from primary disease to lymph node metastases (p < 0.001). SOX9 expression and the subgroup SOX2lowSOX9high were significantly correlated with worse overall survival (p < 0.05). Additionally, SOX2lowSOX9high expression pattern was confirmed as independent prognosticator for overall survival.
Conclusions
These results indicate the relevant role of SOX2 and SOX9 in patients with OSCC and show the clinical relevance for further investigation on the molecular mechanisms underlying SOX-related gene expression.
期刊介绍：
Head & Neck is an international multidisciplinary publication of original contributions concerning the diagnosis and management of diseases of the head and neck. This area involves the overlapping interests and expertise of several surgical and medical specialties, including general surgery, neurosurgery, otolaryngology, plastic surgery, oral surgery, dermatology, ophthalmology, pathology, radiotherapy, medical oncology, and the corresponding basic sciences.
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