再生生病的心脏:干细胞疗法治疗左心发育不全综合征。

IF 0.9 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Annals of Pediatric Cardiology Pub Date : 2024-03-01 Epub Date: 2024-07-20 DOI:10.4103/apc.apc_24_24
Udit Choubey, Varsha Srinivas, Yash Vardhan Trivedi, Nikita Garg, Vasu Gupta, Rohit Jain
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引用次数: 0

摘要

左心发育不全综合征(HLHS)是一种复杂的先天性心脏缺陷(CHD),其特点是左侧心脏结构发育不全。这是一种严重的缺陷,需要进行三阶段手术缓解或心脏移植。尽管外科手术取得了诸多进展,但长期治疗仍面临挑战,发病率和死亡率仍然很高。干细胞治疗HLHS已取得显著进展,包括不同干细胞来源和给药方法的发展。临床试验显示,干细胞治疗具有安全性和潜在益处,包括改善心室功能、减少心力衰竭和减少不良反应。较年轻的心肌似乎特别容易接受干细胞信号,这表明早期干预的重要性。本综述探讨了以干细胞为基础的新兴疗法作为改善HLHS患者预后的辅助方法的潜力。
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Regenerating the ailing heart: Stem cell therapies for hypoplastic left heart syndrome.

Hypoplastic left heart syndrome (HLHS) is a complex congenital heart defect (CHD) characterized by a spectrum of underdeveloped left-sided cardiac structures. It is a serious defect and warrants either 3-staged surgical palliation or a heart transplant. Despite numerous surgical advancements, long-term outcomes remain challenging and still have significant morbidity and mortality. There have been notable advancements in stem cell therapy for HLHS, including developments in diverse stem cell origins and methods of administration. Clinical trials have shown safety and potential benefits, including improved ventricular function, reduced heart failure, and fewer adverse events. Younger myocardium seems particularly receptive to stem cell signals, suggesting the importance of early intervention. This review explores the potential of emerging stem cell-based therapies as an adjunctive approach to improve the outcomes for HLHS patients.

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来源期刊
Annals of Pediatric Cardiology
Annals of Pediatric Cardiology CARDIAC & CARDIOVASCULAR SYSTEMS-
CiteScore
1.40
自引率
14.30%
发文量
51
审稿时长
23 weeks
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