平衡心理:走向全面了解肠道微生物群、炎症和重度抑郁症之间的相互作用》。

IF 3.5 3区 医学 Q2 NEUROSCIENCES Brain Research Bulletin Pub Date : 2024-08-23 DOI:10.1016/j.brainresbull.2024.111056
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引用次数: 0

摘要

肠道微生物群与平衡之间错综复杂的相互作用延伸到了大脑领域,新的研究强调了微生物群对情绪调节和整体神经系统健康的重要影响,反之亦然,而炎症在介导这些复杂的相互作用中起着关键作用。这篇综合性综述探讨了炎症、肠道微生物群的改变及其对重度抑郁障碍(MDD)的影响之间复杂的相互作用。它为这三者之间的拼图提供了一个连贯的框架,强调了在理解肠道微生物群和炎症状态对抑郁特征的影响方面的最新进展。文章讨论了抑郁症患者肠道与大脑之间沟通的两个方向,其中炎症是一个潜在的调节因素。此外,还讨论了治疗意义,从益生菌对肠道细菌组成和抑郁症状影响的干预研究中汲取启示。最终,这篇综述将试图为未来对 MDD 的研究和治疗干预提供一个完整而有价值的框架。
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Balancing the mind: Toward a complete picture of the interplay between gut microbiota, inflammation and major depressive disorder

The intricate interplay existing between gut microbiota and homeostasis extends to the realm of the brain, where emerging research underscores the significant impact of the microbiota on mood regulation and overall neurological well-being and vice-versa, with inflammation playing a pivotal role in mediating these complex interactions. This comprehensive review explores the complex interplay between inflammation, alterations in gut microbiota, and their impact on major depressive disorder (MDD). It provides a cohesive framework for the puzzle pieces of this triad, emphasizing recent advancements in understanding the gut microbiota and inflammatory states' contribution to the depressive features. Two directions of communication between the gut and the brain in depression are discussed, with inflammation serving as a potential modulator. Therapeutic implications were discussed as well, drawing insights from interventional studies on the effects of probiotics on gut bacterial composition and depressive symptoms. Ultimately, this review will attempt to provide a complete and valuable framework for future research and therapeutic interventions in MDD.

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来源期刊
Brain Research Bulletin
Brain Research Bulletin 医学-神经科学
CiteScore
6.90
自引率
2.60%
发文量
253
审稿时长
67 days
期刊介绍: The Brain Research Bulletin (BRB) aims to publish novel work that advances our knowledge of molecular and cellular mechanisms that underlie neural network properties associated with behavior, cognition and other brain functions during neurodevelopment and in the adult. Although clinical research is out of the Journal''s scope, the BRB also aims to publish translation research that provides insight into biological mechanisms and processes associated with neurodegeneration mechanisms, neurological diseases and neuropsychiatric disorders. The Journal is especially interested in research using novel methodologies, such as optogenetics, multielectrode array recordings and life imaging in wild-type and genetically-modified animal models, with the goal to advance our understanding of how neurons, glia and networks function in vivo.
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