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引用次数: 0
摘要
目前,脊髓成像主要使用磁共振成像(MRI)或计算机断层扫描(CT),但正电子发射断层扫描(PET)技术更高的灵敏度和新型放射性racer的开发正在为新方法铺平道路。有关正电子发射计算机断层成像(PET)放射性核素用于脊髓探查的论文大量增加,表明人们对这一器官的功能和分子成像越来越感兴趣。本综述旨在概述临床前和临床环境中用于该适应症的各种放射性核素。首先,我们概述了脊髓解剖结构和相关靶点病理。其次,我们介绍了临床实践中使用的最先进的脊髓成像技术,以及它们各自的优势和局限性。第三,我们总结了脊髓功能 PET 成像中使用的放射性racer 的文献。最后,我们提出了用于脊髓分子成像的理想放射性示踪剂的标准,强调了多模态混合相机的相关性,尤其是 PET-MRI 集成的优势。
At present, spinal cord imaging primarily uses magnetic resonance imaging (MRI) or computed tomography (CT), but the greater sensitivity of positron emission tomography (PET) techniques and the development of new radiotracers are paving the way for a new approach. The substantial rise in publications on PET radiotracers for spinal cord exploration indicates a growing interest in the functional and molecular imaging of this organ. The present review aimed to provide an overview of the various radiotracers used in this indication, in preclinical and clinical settings. Firstly, we outline spinal cord anatomy and associated target pathologies. Secondly, we present the state-of-the-art of spinal cord imaging techniques used in clinical practice, with their respective strengths and limitations. Thirdly, we summarize the literature on radiotracers employed in functional PET imaging of the spinal cord. In conclusion, we propose criteria for an ideal radiotracer for molecular spinal cord imaging, emphasizing the relevance of multimodal hybrid cameras, and particularly the benefits of PET-MRI integration.
期刊介绍:
Seminars in Nuclear Medicine is the leading review journal in nuclear medicine. Each issue brings you expert reviews and commentary on a single topic as selected by the Editors. The journal contains extensive coverage of the field of nuclear medicine, including PET, SPECT, and other molecular imaging studies, and related imaging studies. Full-color illustrations are used throughout to highlight important findings. Seminars is included in PubMed/Medline, Thomson/ISI, and other major scientific indexes.