低频深部脑刺激对一名震颤和小脑共济失调患者的影响

IF 2.5 Q2 CLINICAL NEUROLOGY Tremor and Other Hyperkinetic Movements Pub Date : 2024-08-21 eCollection Date: 2024-01-01 DOI:10.5334/tohm.925
Ami Kumar, Kristen L Matulis, Zena A Fadel, Alexander S Fanning, Christian J Amlang, Sheng-Han Kuo
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引用次数: 0

摘要

背景:对尾椎内侧带(cZi)进行低频脑深部刺激(DBS)是否能改善小脑共济失调症状仍是一个未知数:我们报告了一名 66 岁男性的病例,他最初被诊断为本质性震颤,在植入双侧 cZi DBS 后出现了小脑共济失调。我们测试了低频 DBS 刺激(假、10 Hz、15 Hz、30 Hz)对共济失调严重程度的影响:讨论:低频 cZi DBS 可改善该患者在 30 Hz 频率下的共济失调言语,但在 10 Hz 或 15 Hz 频率下没有改善。低频 DBS 并未改善步态或站姿。因此,低频刺激可能在治疗共济失调性言语障碍中发挥作用:本病例研究结果表明,在尾状内侧带进行 30 赫兹的双侧低频 DBS 有可能改善共济失调性言语,但对步态和站姿的影响有限。言语共济失调与内耳后区的关系值得进一步研究。
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Effects of Low-Frequency Deep Brain Stimulation in Bilateral Zona Incerta for a Patient With Tremor and Cerebellar Ataxia.

Background: Whether low-frequency deep brain stimulation (DBS) in the caudal zona incerta (cZi) can improve cerebellar ataxia symptoms remains unexplored.

Case report: We report a 66-year-old man initially diagnosed with essential tremor and subsequently developed cerebellar ataxia after bilateral cZi DBS implantation. We tested the effects of low-frequency DBS stimulations (sham, 10 Hz, 15 Hz, 30 Hz) on ataxia severity.

Discussion: Low-frequency cZi DBS improves ataxic speech at 30 Hz, but not at 10 Hz or 15 Hz in this patient. Low-frequency DBS did not improve gait or stance. Therefore, low-frequency stimulation may play a role in treating ataxic speech.

Highlights: The finding of this case study suggests that bilateral low-frequency DBS at 30 Hz in the caudal zona incerta has the potential to improve ataxic speech but has limited impact on gait and stance. The involvement of zona incerta in speech warrants further investigation.

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来源期刊
CiteScore
4.00
自引率
4.50%
发文量
31
审稿时长
6 weeks
期刊最新文献
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