Sotirios Sachanas, Christina Stefanaki, Leonidas Marinos, Xanthi Yiakoumis, Maria Moschogiannis, Efstathios Koulieris, Maria Efstathopoulou, Gerassimos A Pangalis
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引用次数: 0
摘要
背景/目的:毛细胞白血病(HCL)是一种众所周知的淋巴细胞增生性疾病,主要依靠嘌呤类似物进行有效治疗。然而,这些治疗方法都会带来深刻而持久的免疫抑制。梅克尔细胞癌(MCC)是一种罕见的侵袭性极强的皮肤肿瘤,在免疫力低下的患者中发病率较高:我们报告了一例 HCL 患者的病例,该患者在接受喷司他丁再治疗后病情得到缓解,但却被诊断为 MCC,而喷司他丁会导致 CD4 (+) T 细胞大量减少:我们的病例为免疫抑制与 MCC 发病机制之间存在显著关联的假设提供了进一步的证据支持。
A Rapidly Developing Nodule in a Patient With Hairy Cell Leukemia in Remission: Merkel Cell Carcinoma: A Case Report.
Background/aim: Hairy cell leukemia (HCL) is a well-known lymphoproliferative disease with very effective treatment approaches primarily relying on purine analogues. However, these treatments are associated with profound and prolonged immunosuppression. Merkel cell carcinoma (MCC) is a rare and extremely aggressive skin tumor with an increased incidence in immunocompromised patients.
Case report: We report a case of a patient with HCL who was diagnosed with MCC, while in remission following retreatment with pentostatin, which induced a profound decrease in CD4 (+) T-cells.
Conclusion: Our case provides further evidence supporting the hypothesis of a significant association between immunosuppression and MCC pathogenesis.
期刊介绍:
IN VIVO is an international peer-reviewed journal designed to bring together original high quality works and reviews on experimental and clinical biomedical research within the frames of physiology, pathology and disease management.
The topics of IN VIVO include: 1. Experimental development and application of new diagnostic and therapeutic procedures; 2. Pharmacological and toxicological evaluation of new drugs, drug combinations and drug delivery systems; 3. Clinical trials; 4. Development and characterization of models of biomedical research; 5. Cancer diagnosis and treatment; 6. Immunotherapy and vaccines; 7. Radiotherapy, Imaging; 8. Tissue engineering, Regenerative medicine; 9. Carcinogenesis.