几内亚比绍 18 个月大儿童在接种疫苗前的肝炎和艾滋病毒感染率。

IF 2.6 4区医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Tropical Medicine & International Health Pub Date : 2024-10-01 Epub Date: 2024-08-26 DOI:10.1111/tmi.14045

Alexander Dutschke, Jane Agergaard, Candida Medina, Bo Langhoff Hønge

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引用次数: 0

摘要

研究目的本研究报告了几内亚比绍在引入乙型肝炎疫苗之前儿童乙型肝炎病毒（HBV）的流行情况：方法：横断面研究。方法：横断面研究。2005 年至 2008 年，187 名 18 个月大的儿童参加了疫苗接种试验，并抽取血样检测 HBV（HbsAg、抗-HBs 和抗-HBc）、丙型肝炎病毒（HCV）和 HIV：HBsAg 感染率为 11.2%，任何 HBV 血清学标志物的感染率为 16.0%。没有儿童对丙型肝炎病毒（HCV）呈阳性反应。一名儿童的 HIV-1 阳性：与其他撒哈拉以南非洲国家的免疫前情况相比，HBsAg 的流行率很高，这突出表明了广泛、持续接种 HBV 疫苗的重要性。这项研究表明，在几内亚比绍，大多数 HBV 传播都是在儿童时期横向进行的。

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Prevalence of hepatitis and HIV infection among 18-months old children in Guinea-Bissau before vaccination.

Objectives: This study reports on the prevalence of hepatitis B virus (HBV) in children in Guinea-Bissau before the hepatitis B vaccine was introduced.

Methods: Cross-sectional study. From 2005 to 2008, 187 children aged 18 months were enrolled in a vaccine trial and had blood samples taken to test for HBV (HbsAg, anti-HBs and anti-HBc), hepatitis C virus (HCV) and HIV.

Results: HBsAg prevalence was 11.2% and prevalence of any HBV serological marker was 16.0%. No children were positive for HCV. One was positive for HIV-1.

Conclusions: The prevalence of HBsAg was high compared to other sub-Saharan African countries pre-immunisation, underscoring the importance of broad and sustained HBV vaccination. This study indicates that the majority of HBV transmission is horizontal during childhood in Guinea-Bissau.

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来源期刊

Tropical Medicine & International Health 医学-公共卫生、环境卫生与职业卫生

CiteScore

4.80

自引率

0.00%

发文量

129

审稿时长

6 months

期刊介绍： Tropical Medicine & International Health is published on behalf of the London School of Hygiene and Tropical Medicine, Swiss Tropical and Public Health Institute, Foundation Tropical Medicine and International Health, Belgian Institute of Tropical Medicine and Bernhard-Nocht-Institute for Tropical Medicine. Tropical Medicine & International Health is the official journal of the Federation of European Societies for Tropical Medicine and International Health (FESTMIH).