APE1：神经退行性疾病的关键焦点

IF 6.9 2区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL Biomedicine & Pharmacotherapy Pub Date : 2024-08-26 DOI:10.1016/j.biopha.2024.117332

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摘要

全球老龄化人口的增长导致神经退行性疾病的发病率上升，其特征是中枢神经系统（CNS）结构和功能的逐渐丧失。鉴于神经退行性疾病的高发病率和使人衰弱的性质，迫切需要确定其潜在的生物标志物和新的治疗靶点。Apurinic/apyrimidinic endonuclease 1（APE1）被认为在多种神经退行性疾病中起着重要作用。在阿尔茨海默病、中风、肌萎缩性脊髓侧索硬化症、帕金森病、亨廷顿病和癫痫等疾病中都观察到了 APE1 的异常表达。然而，这种失调是保护性的还是有害的仍不清楚。本综述旨在全面回顾目前对 APE1 参与神经退行性疾病的认识。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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APE1: A critical focus in neurodegenerative conditions

The global growth of the aging population has resulted in an increased prevalence of neurodegenerative diseases, characterized by the progressive loss of central nervous system (CNS) structure and function. Given the high incidence and debilitating nature of neurodegenerative diseases, there is an urgent need to identify potential biomarkers and novel therapeutic targets thereof. Apurinic/apyrimidinic endonuclease 1 (APE1), has been implicated in several neurodegenerative diseases, as having a significant role. Abnormal APE1 expression has been observed in conditions including Alzheimer’s disease, stroke, amyotrophic lateral sclerosis, Parkinson’s disease, Huntington’s disease, and epilepsy. However, whether this dysregulation is protective or harmful remains unclear. This review aims to comprehensively review the current understanding of the involvement of APE1 in neurodegenerative diseases.

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来源期刊

Biomedicine & Pharmacotherapy 医学-药学

CiteScore

11.90

自引率

2.70%

发文量

1621

审稿时长

48 days

期刊介绍： Biomedicine & Pharmacotherapy stands as a multidisciplinary journal, presenting a spectrum of original research reports, reviews, and communications in the realms of clinical and basic medicine, as well as pharmacology. The journal spans various fields, including Cancer, Nutriceutics, Neurodegenerative, Cardiac, and Infectious Diseases.