[压力对小胶质细胞结构和功能的影响]。

Q3 Medicine 生理学报 Pub Date : 2024-08-25
Yu Xiao, Li-Jie Liu
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引用次数: 0

摘要

应激源的激活会破坏机体的平衡,导致释放应激激素,如肾上腺素、去甲肾上腺素和糖皮质激素。此外,新出现的证据强调了压力对小胶质细胞的深远影响,小胶质细胞是驻留在大脑实质中的特化巨噬细胞。应激后,小胶质细胞表现出明显的形态活化和吞噬活性增强。小胶质细胞表达各种受体,使其能够对来自中枢和外周的应激激素做出反应,从而发挥促炎或抗炎作用。在本文中,我们回顾了在研究暴露于应激源诱导的小胶质细胞结构和功能变化方面取得的进展。此外,我们还探讨了应激激素在介导这些应激源对小胶质细胞的影响方面所起的作用。
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[Effects of stress on the structure and function of microglia].

The activation of stressors can disrupt the body's homeostasis, leading to the release of stress hormones such as epinephrine, noradrenaline, and glucocorticoids. Moreover, emerging evidence highlights the profound impact of stress on microglia, which are specialized macrophages residing in the brain's parenchyma. Following stress, microglia exhibit notable morphological activation and increased phagocytic activity. Microglia express various receptors that enable them to respond to stress hormones originating from both central and peripheral sources, thereby exerting pro-inflammatory or anti-inflammatory effects. In this article, we review the advancements in studying the structural and functional changes of microglia induced by exposure to stressors. Additionally, we explore the role of stress hormones in mediating the effects of these stressors on microglia.

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来源期刊
生理学报
生理学报 Medicine-Medicine (all)
CiteScore
1.20
自引率
0.00%
发文量
4820
期刊介绍: Acta Physiologica Sinica (APS) is sponsored by the Chinese Association for Physiological Sciences and Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences (CAS), and is published bimonthly by the Science Press, China. APS publishes original research articles in the field of physiology as well as research contributions from other biomedical disciplines and proceedings of conferences and symposia of physiological sciences. Besides “Original Research Articles”, the journal also provides columns as “Brief Review”, “Rapid Communication”, “Experimental Technique”, and “Letter to the Editor”. Articles are published in either Chinese or English according to authors’ submission.
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