[急性髓性白血病线粒体相关潜在治疗靶点研究的最新进展]。

Q3 Medicine 生理学报 Pub Date : 2024-08-25
Lu Han, Li Liu, Jing Liu
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引用次数: 0

摘要

急性髓细胞白血病(AML)是最常见的白血病类型之一,其特点是恶性程度高、病情发展快,5 年存活率不到 30%。随着年龄的增长,急性髓细胞白血病的发病率和死亡率也在不断上升。过去几十年来,急性髓细胞白血病的治疗进展相对缓慢。化疗和造血干细胞移植等传统方法存在治疗毒性和化疗耐药性等显著局限性,而近年来对急性髓细胞性白血病机制的深入研究使靶向治疗成为治疗急性髓细胞性白血病的新选择。代谢重编程是癌症的主要特征之一,线粒体功能障碍已在各种癌症中得到广泛研究。线粒体功能障碍普遍存在于急性髓细胞白血病细胞中,并与急性髓细胞白血病的发展密切相关。急性髓细胞性白血病细胞在能量代谢、自噬、细胞凋亡等方面与正常造血细胞存在明显差异。鉴于线粒体是细胞能量代谢的核心,抑制与线粒体功能相关的通路对治疗急性髓细胞白血病具有重大潜力。本综述旨在探讨线粒体功能障碍在急性髓细胞性白血病细胞存活中的作用、线粒体的潜在治疗靶点以及相关靶向药物的最新进展,旨在为急性髓细胞性白血病靶向疗法的开发提供思路。
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[Recent advances in the study of potential mitochondria-related therapeutic targets in acute myeloid leukemia].

Acute myeloid leukemia (AML), one of the most common types of leukemia, is characterized by its high malignancy and rapid progression with a 5-year survival rate of less than 30%. The incidence and mortality rates of AML are increasing with age. Over the past few decades, progress in AML treatment has been relatively slow. While traditional approaches such as chemotherapy and hematopoietic stem cell transplantation have significant limitations including treatment toxicity and chemotherapy resistance, recent advancements in the in-depth study of AML mechanisms have made targeted therapy a new option for AML treatment. Metabolic reprogramming is one of the key features of cancer, and mitochondrial dysfunction has been widely studied in various cancers. Mitochondrial dysfunction is prevalent in AML cells and closely associated with the development of AML. The AML cells exhibit significant differences from normal hematopoietic cells in energy metabolism, autophagy, apoptosis, and other aspects. Given that mitochondria are at the core of cellular energy metabolism, inhibiting pathways related to mitochondrial function holds significant potential for AML treatment. This review aims to explore recent advances on the role of mitochondrial dysfunction in AML cell survival, potential therapeutic targets in mitochondria, and related targeted drugs, aiming to provide ideas for the development of targeted therapies for AML.

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来源期刊
生理学报
生理学报 Medicine-Medicine (all)
CiteScore
1.20
自引率
0.00%
发文量
4820
期刊介绍: Acta Physiologica Sinica (APS) is sponsored by the Chinese Association for Physiological Sciences and Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences (CAS), and is published bimonthly by the Science Press, China. APS publishes original research articles in the field of physiology as well as research contributions from other biomedical disciplines and proceedings of conferences and symposia of physiological sciences. Besides “Original Research Articles”, the journal also provides columns as “Brief Review”, “Rapid Communication”, “Experimental Technique”, and “Letter to the Editor”. Articles are published in either Chinese or English according to authors’ submission.
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