[芳基烃受体(AhR)参与环境污染物对雄性哺乳动物生育能力的影响及其内在机制]。

Q3 Medicine 生理学报 Pub Date : 2024-08-25
Ye-Bin Yang, Zhen Peng, Sheng-Lin Peng, Guang-Quan Mei, Yi-Min Cheng
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引用次数: 0

摘要

近几十年来,全球精液质量持续下降,环境污染成为主要因素。持久性有机污染物(POPs)因其强大的生物毒性和抗自然降解性而备受关注。在这一类污染物中,多环芳香烃(PAHs)和卤代芳香烃(HAHs)已被确定为有害物质,可通过激活芳基烃受体(AhR)破坏细胞的生理功能。然而,人们对 AhR 在环境污染物对雄性哺乳动物生育力的不利影响中所起的确切作用仍不甚了解。本文全面综述了各种环境污染物,特别是多环芳烃(如苯并[a]芘、3-甲基胆蒽、7,12-二甲基苯并[a]蒽)、HAHs(包括 2,3,7,8-四氯二苯并-对-二恶英)、多氯联苯、多溴联苯醚、污染物复合物 PM2.5 以及香烟烟雾冷凝物对雄性哺乳动物生殖功能的影响。此外,本综述还重点探讨了 AhR 在介导这些影响方面的作用。本综述旨在阐明 AhR 参与调节雄性哺乳动物的生育能力,从而为前瞻性研究 AhR 与男性生殖功能之间的相互作用以及临床上特发性男性不育症的病因提供启示。
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[The involvement and underlying mechanism of the aryl hydrocarbon receptor (AhR) in the impairment of male mammalian fertility induced by environmental pollutants].

In recent decades, there has been a consistent decline in semen quality across the globe, with environmental pollution emerging as the predominant factor. Persistent organic pollutants (POPs) have garnered considerable attention due to their potent biological toxicity and resistance to natural degradation. Within this class of pollutants, polycyclic aromatic hydrocarbons (PAHs) and halogenated aromatic hydrocarbons (HAHs) have been identified as detrimental agents that can disrupt cellular physiological functions by activating aryl hydrocarbon receptor (AhR). However, the precise role of AhR in the adverse effects of environmental pollutants on male mammalian fertility remains incompletely understood. This article provides a comprehensive review of the impact of various environmental pollutants, specifically PAHs such as benzo[a]pyrene, 3-methylcholanthrene, and 7,12-dimethylbenzo[a]anthracene, HAHs including 2,3,7,8-tetrachlorodibenzo-p-dioxins, polychlorinated biphenyls, polybrominated diphenyl ethers, and the pollutant complex PM2.5, as well as cigarette smoke condensates, on male mammalian reproductive function. Additionally, this review focuses on the role of the AhR in mediating these effects. The objective of this review is to elucidate the involvement of AhR in the regulation of male mammalian fertility, thereby offering insights for prospective investigations into the interplay between AhR and male reproductive function, as well as the etiology of idiopathic male infertility in clinic.

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来源期刊
生理学报
生理学报 Medicine-Medicine (all)
CiteScore
1.20
自引率
0.00%
发文量
4820
期刊介绍: Acta Physiologica Sinica (APS) is sponsored by the Chinese Association for Physiological Sciences and Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences (CAS), and is published bimonthly by the Science Press, China. APS publishes original research articles in the field of physiology as well as research contributions from other biomedical disciplines and proceedings of conferences and symposia of physiological sciences. Besides “Original Research Articles”, the journal also provides columns as “Brief Review”, “Rapid Communication”, “Experimental Technique”, and “Letter to the Editor”. Articles are published in either Chinese or English according to authors’ submission.
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