治疗肥厚性疤痕的潜在天然产品证据。

IF 3.3 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE Journal of Evidence-based Integrative Medicine Pub Date : 2024-01-01 DOI:10.1177/2515690X241271948
Thunyaluk Meetam, Apichai Angspatt, Pornanong Aramwit
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引用次数: 0

摘要

增生性疤痕是受伤后重建真皮完整性的一种异常伤口愈合反应,可导致身体、美观、功能和心理症状的明显异常,影响患者的生活质量。目前还没有预防和治疗增生性疤痕的金标准。因此,许多研究人员试图寻找疗效更好、副作用更小的抗增生性疤痕药物。天然疗法因其高效性、安全性、生物相容性、低成本和易获得性,正逐渐成为具有吸引力的潜在抗疤痕替代药物。本综述从作用机制、疗效和安全性证据、用作抗瘢痕药物时的优势和劣势等方面展示了各种基于天然产品的疗法,包括洋葱、维生素 E、哥度柯拉、绿茶、白藜芦醇、大黄素、姜黄素等。我们根据体外、体内和临床试验的数据查阅了相关文献。本综述共确定了 23 项临床试验;大多数临床试验结果不确定(证据等级 2b;n = 16)。虽然这些天然产品在体外和体内潜在抗瘢痕研究中均显示出有益作用,但由于研究质量有限,个别缺陷包括样本量小、随机性差、盲法和随访时间短,因此支持其疗效的临床证据有限。要明确这些药物的益处和风险,需要进行更多大规模、设计良好、随访时间长的临床试验。
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Evidence of Potential Natural Products for the Management of Hypertrophic Scars.

Hypertrophic scarring is an aberrant wound-healing response to reestablish dermal integrity after an injury and can cause significant abnormalities in physical, aesthetic, functional, and psychological symptoms, impacting the patient's quality of life. There is currently no gold standard for preventing and treating hypertrophic scars. Therefore, many researchers have attempted to search for antihypertrophic scar agents with greater efficacy and fewer side effects. Natural therapeutics are becoming attractive as potential alternative anti-scarring agents because of their high efficacy, safety, biocompatibility, low cost, and easy accessibility. This review demonstrates various kinds of natural product-based therapeutics, including onion, vitamin E, Gotu kola, green tea, resveratrol, emodin, curcumin, and others, in terms of their mechanisms of action, evidence of efficacy and safety, advantages, and disadvantages when used as anti-scarring agents. We reviewed the literature based on data from in vitro, in vivo, and clinical trials. A total of 23 clinical trials were identified in this review; most clinical trials were ranked as having uncertain results (level of evidence 2b; n = 16). Although these natural products showed beneficial effects in both in vitro and in vivo studies of potential anti-scarring agents, there was limited clinical evidence to support their efficacy due to the limited quality of the studies, with individual flaws including small sample sizes, poor randomization, and blinding, and short follow-up durations. More robust and well-designed clinical trials with large-scale and prolonged follow-up durations are required to clarify the benefits and risks of these agents.

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来源期刊
Journal of Evidence-based Integrative Medicine
Journal of Evidence-based Integrative Medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-
CiteScore
5.90
自引率
0.00%
发文量
43
审稿时长
15 weeks
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