人工智能替代神经学中的动物实验:潜力、进展与挑战。

IF 3.2 Q2 CLINICAL NEUROLOGY Neurology International Pub Date : 2024-07-29 DOI:10.3390/neurolint16040060
Thorsten Rudroff
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引用次数: 0

摘要

长期以来,动物实验一直是神经学研究的基石,但它面临着日益严峻的科学、伦理和经济挑战。人工智能(AI)的进步为以更贴近人类、更高效的方法取代动物实验提供了新的机遇。本文探讨了人工智能技术(如脑器质、计算模型和机器学习)在革新神经病学研究和减少对动物模型的依赖方面的潜力。这些方法可以更好地再现人脑生理学、预测药物反应并揭示神经系统疾病的新见解。它们还提供了更快、更便宜、更符合道德规范的动物实验替代品。案例研究表明,人工智能能够加速阿尔茨海默氏症的药物发现、预测神经毒性、个性化治疗帕金森氏症以及恢复瘫痪患者的运动能力。虽然在验证和整合这些技术方面仍存在挑战,但科学、经济、实用和道德方面的优势正在推动神经学研究向基于人工智能、不使用动物的模式转变。通过持续投资和跨部门合作,人工智能有望加速开发更安全、更有效的神经疾病疗法,同时大幅减少动物的使用。前进的道路上需要不断开发和验证这些技术,但在未来,它们在很大程度上取代神经病学动物实验的可能性似乎越来越大。这一转变预示着一个更加人道、与人类相关和创新的脑研究新时代的到来。
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Artificial Intelligence as a Replacement for Animal Experiments in Neurology: Potential, Progress, and Challenges.

Animal experimentation has long been a cornerstone of neurology research, but it faces growing scientific, ethical, and economic challenges. Advances in artificial intelligence (AI) are providing new opportunities to replace animal testing with more human-relevant and efficient methods. This article explores the potential of AI technologies such as brain organoids, computational models, and machine learning to revolutionize neurology research and reduce reliance on animal models. These approaches can better recapitulate human brain physiology, predict drug responses, and uncover novel insights into neurological disorders. They also offer faster, cheaper, and more ethical alternatives to animal experiments. Case studies demonstrate AI's ability to accelerate drug discovery for Alzheimer's, predict neurotoxicity, personalize treatments for Parkinson's, and restore movement in paralysis. While challenges remain in validating and integrating these technologies, the scientific, economic, practical, and moral advantages are driving a paradigm shift towards AI-based, animal-free research in neurology. With continued investment and collaboration across sectors, AI promises to accelerate the development of safer and more effective therapies for neurological conditions while significantly reducing animal use. The path forward requires the ongoing development and validation of these technologies, but a future in which they largely replace animal experiments in neurology appears increasingly likely. This transition heralds a new era of more humane, human-relevant, and innovative brain research.

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来源期刊
Neurology International
Neurology International CLINICAL NEUROLOGY-
CiteScore
3.70
自引率
3.30%
发文量
69
审稿时长
11 weeks
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