青春期生长突增的新概念。

R Stanhope, M A Preece, D B Grant, C G Brook
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引用次数: 0

摘要

正常儿童生长突增的时间并不影响他们最终达到的身高。青春期生长加速期间的生长速率与生长激素的变化有关,而与性类固醇分泌无关。生长激素分泌在青春期是脉冲幅度,而不是频率,调制。在GnRH类似物抑制的中枢性性早熟和正常青春期中,骨骺成熟的速度、GH脉冲幅度和生长都有所下降,但对最终高度没有影响。
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New concepts of the growth spurt of puberty.

The timing of the growth spurt of normal children does not affect their final height attainment. Growth rate during the growth acceleration of puberty correlates with changes in GH, and not sex steroid, secretion. GH secretion during puberty is pulse amplitude, and not frequency, modulated. In both central precocious puberty and normal puberty suppressed with a GnRH analogue, the rate of epiphyseal maturation is decreased as are GH pulse amplitude and growth, but with no influence on final height.

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11th International Symposium on Growth and Growth Disorders. Proceedings of a meeting, Stockholm, Sweden, 26-27 April 1991. 12th International Symposium on Growth and Growth Disorders. Geneva, 25-26 October 1991. The carbohydrate-deficient glycoprotein syndrome. A new inherited multisystemic disease with severe nervous system involvement. Growth hormone treatment in short children with chronic renal failure and after renal transplantation: combined data from European clinical trials. The European Study Group. Growth response in prepubertal children with idiopathic growth hormone deficiency during the first two years of treatment with human growth hormone. Analysis of the Kabi Pharmacia International Growth Study.
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