维生素 D 与曲安奈德治疗瘢痕疙瘩的比较。

IF 0.9 Q3 SURGERY World Journal of Plastic Surgery Pub Date : 2024-01-01 DOI:10.61186/wjps.13.2.44
Nader Pazyar, Sedigheh Sananzadeh, Reza Yaghoobi, Nima Bakhtiari
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引用次数: 0

摘要

背景:肥厚性疤痕和瘢痕疙瘩是结缔组织过度增生引起的疾病,与胶原蛋白和细胞基质成分的堆积有关。这些疤痕是由于伤口愈合异常引起的,会对患者的生活造成很大影响。因此,我们旨在比较点内注射维生素 D 与曲安奈德治疗瘢痕疙瘩的效果:本研究是一项单侧盲法临床试验,对象为 22 例瘢痕疙瘩患者(44 个样本)。这是一项随机、盲法临床试验,于 2022 年在伊朗阿瓦士的伊玛目霍梅尼医院进行。每组在病变部位注射曲安奈德或维生素 D,间隔三周,平均 6 次。治疗结束 3 个月后,重新评估患者的复发情况:通过检查各组的 VSS 量表,干预后两组的 VSS 量表均显著下降(P=0.001),其中接受曲安奈德治疗组的 VSS 量表下降幅度更大(P=0.001):看来,在病变部位注射维生素 D 有助于治疗,但通常的三苯氧胺治疗效果仍较高,建议将维生素 D 作为此类患者的辅助治疗手段。
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Comparison of Intralesional Vitamin D with Intralesional Triamcinolone Acetonide in the Treatment of Keloids.

Background: Hypertrophic scars and keloids are disorders caused by the excessive growth of connective tissue, associated with the accumulation of collagen and cellular matrix components. These scars are caused by abnormal wound healing and can have a great impact on patients' lives. Therefore, we aimed to compare the effect of intralesional injection of vitamin D with triamcinolone acetonide in the treatment of keloid.

Methods: This study was a one-sided blind clinical trial, conducted on 22 patients (44 samples) with keloid. It was a randomized, blinded clinical trial, conducted in Imam Khomeini Hospital in Ahvaz, Iran in 2022. In each group, triamcinolone or vitamin D was injected at the lesion site with an interval of three weeks and an average of 6 sessions. The patients were re-evaluated 3 months after the end of the treatment in terms of recurrence.

Results: By examining the VSS scale in each of the groups, this scale decreased significantly in both groups after the intervention (P=0.001), which was greater in the group receiving triamcinolone (P=0.001).

Conclusion: It seems that the injection of vitamin D at the site of the lesion helps to treat it, but the effectiveness of the usual triamcinolone treatment was still higher, it is suggested to use vitamin D as an adjunctive treatment in these patients.

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