个性化医疗:从分子角度看临床肿瘤治疗。

IF 2.6 Q3 ONCOLOGY World journal of clinical oncology Pub Date : 2024-08-24 DOI:10.5306/wjco.v15.i8.992
Rafick Costa Dos Santos Da Silva, Nathalia de Andrade Simon, André Alves Dos Santos, Gabriel De Melo Olegário, Jayne Ferreira Da Silva, Naide Oliveira Sousa, Manuel Alvarez Troncoso Corbacho, Fabrício Freire de Melo
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引用次数: 0

摘要

癌症是全球第二大死因,对患者的身体和情感都造成了影响。手术、化疗和放疗等传统治疗方法会产生不良影响,因此需要更精确的方法。精准医疗可以实现更有针对性的治疗。基因图谱和其他分子生物学方法可识别特定基因,有助于准确预后。这篇综述从分子角度探讨了临床应用中的治疗问题。探讨了甲胎蛋白、β-人绒毛膜促性腺激素、5-羟基吲哚乙酸、程序性死亡-1 和细胞毒性 T 淋巴细胞相关蛋白 4 等生物标志物,提供了有价值的信息。以人工智能为重点的生物信息学彻底改变了对生物数据的分析,提供了更准确的诊断。液体活检等技术被强调用于早期检测。精准医学根据肿瘤的分子特征指导治疗策略,乳腺癌的分子亚型就是证明。通过分类可以进行个性化治疗,突出了曲妥珠单抗和内分泌疗法的作用。尽管好处多多,但挑战依然存在,包括高成本、肿瘤异质性和伦理问题。克服障碍需要合作,确保分子生物学的进步转化为所有人都能享受到的益处。
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Personalized medicine: Clinical oncology on molecular view of treatment.

Cancer, the second leading global cause of death, impacts both physically and emotionally. Conventional treatments such as surgeries, chemotherapy, and radiotherapy have adverse effects, driving the need for more precise approaches. Precision medicine enables more targeted treatments. Genetic mapping, alongside other molecular biology approaches, identifies specific genes, contributing to accurate prognoses. The review addresses, in clinical use, a molecular perspective on treatment. Biomarkers like alpha-fetoprotein, beta-human chorionic gonadotropin, 5-hydroxyindoleacetic acid, programmed death-1, and cytotoxic T lymphocyte-associated protein 4 are explored, providing valuable information. Bioinformatics, with an emphasis on artificial intelligence, revolutionizes the analysis of biological data, offering more accurate diagnoses. Techniques like liquid biopsy are emphasized for early detection. Precision medicine guides therapeutic strategies based on the molecular characteristics of the tumor, as evidenced in the molecular subtypes of breast cancer. Classifications allow personalized treatments, highlighting the role of trastuzumab and endocrine therapies. Despite the benefits, challenges persist, including high costs, tumor heterogeneity, and ethical issues. Overcoming obstacles requires collaboration, ensuring that advances in molecular biology translate into accessible benefits for all.

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期刊介绍: The WJCO is a high-quality, peer reviewed, open-access journal. The primary task of WJCO is to rapidly publish high-quality original articles, reviews, editorials, and case reports in the field of oncology. In order to promote productive academic communication, the peer review process for the WJCO is transparent; to this end, all published manuscripts are accompanied by the anonymized reviewers’ comments as well as the authors’ responses. The primary aims of the WJCO are to improve diagnostic, therapeutic and preventive modalities and the skills of clinicians and to guide clinical practice in oncology. Scope: Art of Oncology, Biology of Neoplasia, Breast Cancer, Cancer Prevention and Control, Cancer-Related Complications, Diagnosis in Oncology, Gastrointestinal Cancer, Genetic Testing For Cancer, Gynecologic Cancer, Head and Neck Cancer, Hematologic Malignancy, Lung Cancer, Melanoma, Molecular Oncology, Neurooncology, Palliative and Supportive Care, Pediatric Oncology, Surgical Oncology, Translational Oncology, and Urologic Oncology.
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