在心脏代谢疾病中走 "VLDL钢丝"。

IF 11.4 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM Trends in Endocrinology and Metabolism Pub Date : 2024-08-26 DOI:10.1016/j.tem.2024.07.020
Mindy Kim, Ze Zheng
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引用次数: 0

摘要

极低密度脂蛋白(VLDL)是一种由肝细胞分泌的富含甘油三酯的脂蛋白,是为外周组织提供脂肪酸以产生能量的关键。就像走钢丝一样,VLDL 代谢平衡的紊乱会导致心脏代谢功能障碍,引发心血管疾病(CVD)或代谢功能障碍相关性脂肪肝(MASLD)等病症。尽管降脂疗法(包括他汀类药物和9型丙蛋白转换酶亚基酶/kexin(PCSK9)抑制剂)已经问世,但心血管事件的风险依然存在。由于目前可用的心血管疾病治疗方法有限,而且没有美国食品药品管理局(FDA)批准的治疗 MASLD 的方法,本综述总结了目前对 VLDL 代谢的理解,揭示了治疗心血管代谢紊乱的新途径。
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Walking the VLDL tightrope in cardiometabolic diseases.

Very-low-density lipoprotein (VLDL), a triglyceride-rich lipoprotein secreted by hepatocytes, is pivotal for supplying peripheral tissues with fatty acids for energy production. As if walking on a tightrope, perturbations in the balance of VLDL metabolism contribute to cardiometabolic dysfunction, promoting pathologies such as cardiovascular disease (CVD) or metabolic dysfunction-associated steatotic liver disease (MASLD). Despite the advent of lipid-lowering therapies, including statins and proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors, risks for cardiovascular events persist. With limitations to currently available CVD therapeutics and no US Food and Drug Administration (FDA)-approved treatment for MASLD, this review summarizes the current understanding of VLDL metabolism that sheds light on novel therapeutic avenues to pursue for cardiometabolic disorders.

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来源期刊
Trends in Endocrinology and Metabolism
Trends in Endocrinology and Metabolism 医学-内分泌学与代谢
CiteScore
20.10
自引率
0.00%
发文量
98
审稿时长
82 days
期刊介绍: Trends in Endocrinology and Metabolism (TEM) stands as a premier Reviews journal in the realms of metabolism and endocrinology. Our commitment is reflected in the publication of refined, concise, and highly impactful articles that delve into cutting-edge topics, encompassing basic, translational, and clinical aspects. From state-of-the-art treatments for endocrine diseases to groundbreaking developments in molecular biology, TEM provides comprehensive coverage. Explore recent advancements in diabetes, endocrine diseases, obesity, neuroendocrinology, immunometabolism, molecular and cellular biology, and a myriad of other areas through our journal. TEM serves as an invaluable resource for researchers, clinicians, lecturers, teachers, and students. Each monthly issue is anchored by Reviews and Opinion articles, with Reviews meticulously chronicling recent and significant developments, often contributed by leading researchers in specific fields. Opinion articles foster debate and hypotheses. Our shorter pieces include Science & Society, shedding light on issues at the intersection of science, society, and policy; Spotlights, which focus on exciting recent developments in the literature, and single-point hypotheses as Forum articles. We wholeheartedly welcome and encourage responses to previously published TEM content in the form of Letters.
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