减肥手术后,奖赏区对甜味的神经处理会减少。

IF 4.2 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Obesity Pub Date : 2024-08-28 DOI:10.1002/oby.24103
Jonathan Alessi, Mario Dzemidzic, Jaroslaw Harezlak, David A. Kareken, Robert V. Considine
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引用次数: 0

摘要

目的:减肥手术会减少对甜食的喜好,但其机制仍不清楚。我们研究了相关的大脑反应:我们共招募了 24 名体重正常至超重的非糖尿病减肥手术参与者和 21 名对照组参与者,进行了一项观察性对照队列研究。他们在扫描仪外接受了蔗糖味觉测试,随后在功能磁共振成像中接受了 0.40M 和 0.10M 蔗糖与水的刺激。共有 21 名减肥参与者在手术后重复了这些过程:结果:对照组、术前组和术后组对甜味强度的感知没有差异。手术后,减肥参与者首选的甜味浓度降低(0.52M 降至 0.29M;p = 0.008)。大脑奖赏系统(腹侧被盖区、腹侧纹状体和眶额皮层)感兴趣区分析表明,手术后 0.40M 蔗糖激活减少(但 0.10M 没有减少)。感觉区(初级躯体感觉皮层和初级味觉皮层)0.40M蔗糖激活在手术后没有变化,对照组和减肥参与者之间也没有差异。与对照组参与者相比,手术后减肥参与者的初级味觉皮层对0.10M蔗糖溶液的激活程度更高:减肥手术降低了肥胖女性对甜味的奖赏系统反应,但没有影响感觉区域的活动,这与摄入甜味食物的驱动力降低是一致的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Neural processing of sweet taste in reward regions is reduced following bariatric surgery

Objective

Bariatric surgery reduces sweet-liking, but mechanisms remain unclear. We examined related brain responses.

Methods

A total of 24 nondiabetic bariatric surgery and 21 control participants with normal weight to overweight were recruited for an observational controlled cohort study. They underwent sucrose taste testing outside the scanner followed by stimulation with 0.40M and 0.10M sucrose compared with water during functional magnetic resonance imaging. A total of 21 bariatric participants repeated these procedures after surgery.

Results

Perceived sweet intensity was not different among the control, presurgery, or postsurgery groups. Bariatric participants' preferred sweet concentration decreased after surgery (0.52M to 0.29M; p = 0.008). Brain reward system (ventral tegmental area, ventral striatum, and orbitofrontal cortex) region of interest analysis showed that 0.40M sucrose activation  (but not 0.10M) decreased after surgery. Sensory region (primary somatosensory and primary taste cortex) 0.40M sucrose activation was unchanged by surgery and did not differ between control and bariatric participants. Primary taste cortex activation to 0.10M sucrose solution was greater in postsurgical bariatric participants compared with control participants.

Conclusions

Bariatric surgery reduces the reward system response to sweet taste in women with obesity without affecting activity in sensory regions, which is consistent with reduced drive to consume sweet foods.

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来源期刊
Obesity
Obesity 医学-内分泌学与代谢
CiteScore
11.70
自引率
1.40%
发文量
261
审稿时长
2-4 weeks
期刊介绍: Obesity is the official journal of The Obesity Society and is the premier source of information for increasing knowledge, fostering translational research from basic to population science, and promoting better treatment for people with obesity. Obesity publishes important peer-reviewed research and cutting-edge reviews, commentaries, and public health and medical developments.
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Issue Information Poster Abstracts Oral Abstracts Issue Information Cardiometabolic characteristics of weight cycling: results from a mid-South regional comprehensive health care system
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