儿童多系统炎症疾病的长期细胞因子概况

IF 3.7 3区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Cytokine Pub Date : 2024-08-27 DOI:10.1016/j.cyto.2024.156744
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引用次数: 0

摘要

背景儿童多系统炎症性疾病(MIS-C)是冠状病毒病-19 感染后的一种后发疾病。长期随访数据表明,最初的临床严重程度并不一定与长期预后相关。人们对 MIS-C 儿童的长期免疫反应仍然知之甚少。我们分析了 MIS-C 儿童患者在诊断和随访期间的细胞因子谱,探讨了细胞因子表达与标准生化和激素检测结果之间的相关性。部分细胞因子,如 IL-9、eotaxin、IP-10、MIP-1β、RANTES、MCP-1(MCAF)、TNF-α、PDGF-B、IL-4 和 MIP-1α 被纳入分析。结果 IP-10、MCP-1(MCAF)和MIP-1α的水平在6-12个月时恢复正常或接近正常,其余细胞因子,包括IL-9、eotaxin、MIP-1β、RANTES、TNF-α、PDGF-B、IL-4,在我们最后一次随访时,MIS-C患者的水平仍高于对照组。在确诊后 6 个月,甘油三酯和 HOMA-IR 与 MCP-1 (MCAF)、IL-4 和 Eotaxin 呈轻度负相关。在 12 个月的随访中,我们发现皮质醇和促肾上腺皮质激素水平与 PDGF-B、MIP-1α 和 TNF-α 呈轻度正相关。相反,这些细胞因子与空腹血糖和 HOMA-IR 之间呈负相关。结论:我们的研究结果表明,与对照组相比,MIS-C 儿科患者在 12 个月的监测期间,细胞因子介导的炎症反应持续升高。我们发现了不同细胞因子之间的各种相互关系,以及细胞因子水平升高与代谢和激素模式之间的相关性。明显的炎症反应突显了它与急性器官损伤的关系,而它的持续性则表明了对长期代谢紊乱的潜在影响。
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Long-term cytokine profile in multisystem inflammatory disease among children

Background

Multisystem inflammatory disease in children (MIS-C) is a post-infectious condition following coronavirus disease-19 infection. Long-term follow-up data suggests that initial clinical severity does not necessarily correlate with long-term outcomes. The long-term immunological response in children with MIS-C remains poorly understood. We analyzed cytokine profiles at diagnosis and during follow-up, in pediatric patients with MIS-C, exploring correlations among cytokine expressions and standard biochemical and hormonal test results.

Methods

Twenty-five MIS-C patients (mean 9.4 ± 3.9) with complete test results at diagnosis and at 6- and 12-months follow-up were included in the study. Selected cytokines, such as IL-9, eotaxin, IP-10, MIP-1β, RANTES, MCP-1(MCAF), TNF-α, PDGF-B, IL-4, and MIP-1α, were included in the analysis.

Results

IP-10, MCP-1 (MCAF), and MIP-1α levels normalized or nearly normalized at 6–12 months, the remaining cytokines, including IL-9, eotaxin, MIP-1β, RANTES, TNF-α, PDGF-B, IL-4, remained higher in MIS-C than in controls at our last follow-up time. At 6 months post-diagnosis, a mild negative correlation between triglycerides and HOMA-IR with MCP-1 (MCAF), IL-4, and Eotaxin was noted. At the 12-month follow-up we found a mild positive correlation of cortisol and ACTH levels with PDGF-B, MIP-1α, and TNF-α. Conversely, a negative correlation between these cytokines with fasting glucose and HOMA-IR was observed.

Conclusions

Our study findings highlight a notable cytokine-mediated inflammatory response in pediatric patients with MIS-C, characterized by sustained elevated levels over a 12-month monitoring period compared to the control group. We have identified various interrelationships among different cytokines, as well as correlations between heightened cytokine levels and metabolic and hormonal patterns. The pronounced inflammatory response underscores its involvement in acute organ damage, while its persistence suggests potential implications for long-term metabolic disorders.

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来源期刊
Cytokine
Cytokine 医学-免疫学
CiteScore
7.60
自引率
2.60%
发文量
262
审稿时长
48 days
期刊介绍: The journal Cytokine has an open access mirror journal Cytokine: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. * Devoted exclusively to the study of the molecular biology, genetics, biochemistry, immunology, genome-wide association studies, pathobiology, diagnostic and clinical applications of all known interleukins, hematopoietic factors, growth factors, cytotoxins, interferons, new cytokines, and chemokines, Cytokine provides comprehensive coverage of cytokines and their mechanisms of actions, 12 times a year by publishing original high quality refereed scientific papers from prominent investigators in both the academic and industrial sectors. We will publish 3 major types of manuscripts: 1) Original manuscripts describing research results. 2) Basic and clinical reviews describing cytokine actions and regulation. 3) Short commentaries/perspectives on recently published aspects of cytokines, pathogenesis and clinical results.
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