缺氧诱导因子-1α及其在子宫内膜癌中的作用

IF 1.6 4区医学 Q4 ONCOLOGY Anticancer research Pub Date : 2024-09-01 DOI:10.21873/anticanres.17195

Beata Smolarz, Honorata Łukasiewicz, Dariusz Samulak, Radosław Kołaciński, Sara Langner, Marianna Makowska, Hanna Romanowicz

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引用次数: 0

摘要

转录因子缺氧诱导因子-1（HIF-1）是细胞应对缺氧的主要因子之一。缺氧是肿瘤生长的一个典型特征。在包括子宫内膜癌在内的许多癌症中都能观察到 HIF-1 活性的增加。HIF-1 是一种异源二聚体，由三个亚基 HIF-1α、HIF-2α、HIF-3α 和一个亚基 β 组成。HIF-1α 基因具有高度多态性。文献数据表明，HIF-1α 基因的单核苷酸多态性（SNPs）可能是子宫内膜癌的危险因素。更好地了解癌症发生、发展和预后的分子机制，包括 SNPs 的作用，将有助于开发新的抗癌疗法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Hypoxia-induced Factor-1α and its Role in Endometrial Cancer.

The transcription factor hypoxia inducible factor-1 (HIF-1) is one of the main factors in the cell's response to a lack of oxygen. Hypoxia is a typical feature of a growing cancerous tumor. Increased activity of HIF-1 is observed in many cancers, including endometrial cancer. HIF-1 functions as a heterodimer consisting of three subunits HIF-1α, HIF-2α, and HIF-3α and one subunit β. HIF-1α is a subunit that is sensitive to oxygen concentration and is constitutively expressed. The HIF-1α gene is highly polymorphic. Literature data suggest that single nucleotide polymorphisms (SNPs) of the HIF-1α gene may be risk factors for endometrial cancer. A better understanding of the molecular mechanisms of cancer development, progression and prognosis, including the role of SNPs, could lead to the development of new anti-cancer therapies.

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来源期刊

Anticancer research 医学-肿瘤学

CiteScore

3.70

自引率

10.00%

发文量

566

审稿时长

2 months

期刊介绍： ANTICANCER RESEARCH is an independent international peer-reviewed journal devoted to the rapid publication of high quality original articles and reviews on all aspects of experimental and clinical oncology. Prompt evaluation of all submitted articles in confidence and rapid publication within 1-2 months of acceptance are guaranteed. ANTICANCER RESEARCH was established in 1981 and is published monthly (bimonthly until the end of 2008). Each annual volume contains twelve issues and index. Each issue may be divided into three parts (A: Reviews, B: Experimental studies, and C: Clinical and Epidemiological studies). Special issues, presenting the proceedings of meetings or groups of papers on topics of significant progress, will also be included in each volume. There is no limitation to the number of pages per issue.