原发性甲状腺淋巴瘤多中心回顾性研究

IF 2.7 3区医学 Q1 SURGERY American journal of surgery Pub Date : 2024-08-22 DOI:10.1016/j.amjsurg.2024.115927

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引用次数: 0

摘要

背景原发性甲状腺淋巴瘤（PTL）非常罕见，诊断具有挑战性。方法我们对1990年至2023年的PTL患者进行了一项多中心回顾性研究，以确定诊断方法、治疗和预后。结果研究队列包括31例PTL患者；所有患者均有甲状腺肿大；21例（68%）有压迫症状，11例（35%）有甲状腺功能减退，3例（10%）有B症状。8例（26%）通过切口活检确诊，4例（13%）通过针刺活检确诊，1例（3%）通过切除淋巴结活检确诊，18例（58%）通过甲状腺切除术标本确诊。15例（48%）患者患有桥本甲状腺炎。治疗方法包括：19 例（61%）患者接受化疗；7 例（23%）患者接受单纯手术治疗；5 例（16%）患者接受单纯放疗或手术治疗。1例（3%）患者复发，4例（13%）患者在中位4.2年后死亡。针刺活检可能有助于早期诊断和治疗。

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Primary thyroid lymphoma: A multi-center retrospective review

Background

Primary thyroid lymphoma (PTL) is rare and diagnosis is challenging.

Methods

We conducted a multicenter retrospective study of patients with PTL from 1990 to 2023 to determine method of diagnosis, treatment, and outcomes.

Results

The study cohort included 31 patients with PTL; all had thyroid enlargement; 21 (68 %) had compressive symptoms, 11 (35 %) had hypothyroidism and 3 had (10 %) B symptoms. Diagnosis was established from incisional biopsy in 8 (26 %), needle biopsy in 4 (13 %), excisional lymph node biopsy in 1 (3 %), and thyroidectomy specimens in 18 (58 %). 15 (48 %) patients had Hashimoto thyroiditis. Treatment included chemotherapy in 19 (61 %); surgery alone in 7 (23 %); and radiation alone or with surgery in 5 (16 %) patients. One (3 %) patient recurred, and 4 (13 %) patients died after a median 4.2 years.

Conclusion

Diagnosis of PTL was made in only 13 % of patients preoperatively. There may be opportunity for needle biopsy to facilitate earlier diagnosis and treatment.

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来源期刊

American journal of surgery 医学-外科

CiteScore

5.00

自引率

6.70%

发文量

570

审稿时长

56 days

期刊介绍： The American Journal of Surgery® is a peer-reviewed journal designed for the general surgeon who performs abdominal, cancer, vascular, head and neck, breast, colorectal, and other forms of surgery. AJS is the official journal of 7 major surgical societies* and publishes their official papers as well as independently submitted clinical studies, editorials, reviews, brief reports, correspondence and book reviews.