体细胞基因突变对骨髓纤维化血栓形成风险的影响

IF 12.8 1区 医学 Q1 HEMATOLOGY Leukemia Pub Date : 2024-08-30 DOI:10.1038/s41375-024-02389-2
Irene Pastor-Galán, Arturo Pereira, Eduardo Arellano-Rodrigo, Iván Martín, Adrián Mosquera-Orgueira, María-Teresa Gómez-Casares, Alberto Hernández-Sánchez, Francisca Ferrer-Marín, Elvira Mora, Patricia Velez, Rosa Ayala, Anna Angona, Natalia de las Heras, Elena Magro, María-Isabel Mata-Vázquez, María-Laura Fox, Sonia González de Villambrosía, María-José Ramírez, Ana García, Valentín García-Gutiérrez, Amparo Cáceres, María-Antonia Durán, María-Alicia Senín, José-María Raya, José Antonio González, Beatriz Cuevas, Blanca Xicoy, Marta Garrote, Blanca Ferrer, Manuel Pérez-Encinas, Jesús María Hernández-Rivas, Beatriz Bellosillo, Alberto Álvarez-Larrán, Juan Carlos Hernández-Boluda
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引用次数: 0

摘要

骨髓纤维化(MF)是一种慢性骨髓增生性肿瘤(MPN),以造血祖细胞克隆性增殖、骨髓纤维化和髓外造血为特征。通过 MPN 驱动基因(即 JAK2、CALR 和 MPL)的突变,JAK-STAT 通路信号的持续激活在其发病和进展过程中起着根本性的作用,而其他基因(非 MPN 驱动基因)的突变也会影响其发病和进展[1]。约 20% 的患者在确诊前或确诊时出现血栓形成,6-12% 的患者在随访期间出现血栓事件。血栓形成的主要风险因素包括年龄较大、既往有血栓形成病史和 JAK2 基因突变型 [2,3]。有几项研究评估了非骨髓增生性疾病驱动基因突变作为血栓形成风险因素在原发性血小板增多症(ET)[6, 7]和真性红细胞增多症(PV)[8, 9]中的作用,但它们在中性粒细胞增多症中的作用尚不明确。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Impact of somatic gene mutations on the risk of thrombosis in myelofibrosis
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来源期刊
Leukemia
Leukemia 医学-血液学
CiteScore
18.10
自引率
3.50%
发文量
270
审稿时长
3-6 weeks
期刊介绍: Title: Leukemia Journal Overview: Publishes high-quality, peer-reviewed research Covers all aspects of research and treatment of leukemia and allied diseases Includes studies of normal hemopoiesis due to comparative relevance Topics of Interest: Oncogenes Growth factors Stem cells Leukemia genomics Cell cycle Signal transduction Molecular targets for therapy And more Content Types: Original research articles Reviews Letters Correspondence Comments elaborating on significant advances and covering topical issues
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