酰胺质子转移成像结合血清 CA125 水平在手术前预测宫颈癌淋巴管侵犯中的价值。

IF 1.1 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Acta radiologica Pub Date : 2024-09-01 Epub Date: 2024-08-28 DOI:10.1177/02841851241273939
Chen Xu, Xiao-Yan Zhang, Xing-Chen Wu, Lei Ming, Qian-Qian Qu, Kai Deng
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引用次数: 0

摘要

背景:目的:评估术前酰胺质子转移(APT)成像结合血清CA125水平预测宫颈癌淋巴管间隙侵犯(LVSI)的价值:这项回顾性研究纳入了80例接受术前磁共振成像(包括APT成像)的宫颈癌患者。使用全自动免疫测定分析仪和化学发光法测定血清 CA125 水平。根据术后病理结果确定是否存在 LVSI:在符合要求的 40 例患者中,29 例术后病理证实为 LVSI,11 例未证实。术前 APT 和 CA125 水平预测 LVSI 的接收器操作特征曲线下面积(AUC)分别为 0.889 和 0.687。当 APT 值为 2.9% 时,相应的 Youden 指数最高(0.702),敏感性为 79.3%,特异性为 90.9%。当术前血清 CA15 水平的临界值为 25.3 u/mL 时,相应的尤登指数最高(0.508),敏感性为 69.0%,特异性为 81.8%。术前 APT 成像结合血清 CA125 预测 LVSI 的敏感性和特异性分别为 82.7% 和 100%,尤登指数为 0.828,AUC 为 0.923:结论:术前APT成像与血清CA125水平相结合对预测宫颈癌LVSI很有价值。当 APT 值大于 2.9% 且血清 CA125 水平大于 25.3 u/mL 时,诊断效果最高。
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The value of amide proton transfer imaging combined with serum CA125 levels in predicting lymph vascular invasion in cervical cancer before surgery.

Background: Preoperative prediction of lymphovascular space invasion (LVSI) is crucial for improving the prognosis of patients with cervical cancer.

Purpose: To evaluate the value of preoperative amide proton transfer (APT) imaging combined with serum CA125 levels for predicting LVSI in cervical cancer.

Material and methods: This retrospective study included 80 patients with cervical cancer who underwent preoperative magnetic resonance imaging, including APT imaging. Serum CA125 levels were measured using a fully automated immunoassay analyzer and chemiluminescence method. The presence of LVSI was determined based on the pathological results after surgery.

Results: Among the 40 patients who met the requirements, 29 had postoperative pathological confirmation of LVSI, while 11 did not. The areas under the receiver operating characteristic curves (AUC) of preoperative APT and CA125 levels predicting LVSI were 0.889 and 0.687, respectively. When the APT value was 2.9%, the corresponding Youden index was the highest (0.702), with a sensitivity of 79.3% and specificity of 90.9%. When the critical value of the preoperative serum CA15 level was 25.3 u/mL, the corresponding Youden index was the highest (0.508), with a sensitivity of 69.0% and a specificity of 81.8%. The sensitivity and specificity of preoperative APT imaging combined with serum CA125 in predicting LVSI were 82.7% and 100%, respectively, with a Youden's index of 0.828 and an AUC of 0.923.

Conclusion: The combination of preoperative APT imaging and serum CA125 levels is valuable for predicting LVSI in cervical cancer. Diagnostic efficacy is highest when the APT value is >2.9% and the serum CA125 level is >25.3 u/mL.

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来源期刊
Acta radiologica
Acta radiologica 医学-核医学
CiteScore
2.70
自引率
0.00%
发文量
170
审稿时长
3-8 weeks
期刊介绍: Acta Radiologica publishes articles on all aspects of radiology, from clinical radiology to experimental work. It is known for articles based on experimental work and contrast media research, giving priority to scientific original papers. The distinguished international editorial board also invite review articles, short communications and technical and instrumental notes.
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