揭示小麦多酚保护心脏作用的机制。

IF 4.8 2区 医学 Q1 TOXICOLOGY Archives of Toxicology Pub Date : 2024-08-31 DOI:10.1007/s00204-024-03850-y
Pratik Chakraborty, Saikat Dewanjee
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引用次数: 0

摘要

心血管疾病对全世界人民的预期寿命和生活质量都构成了重大威胁,尤其是在中低收入国家,疾病负担已达到令人担忧的程度。目前使用的几种药物会导致多种不良反应。因此,迫切需要开发安全、经济、有效的心血管疾病治疗药物。新的证据显示,多酚消费与心血管保护之间存在正相关。全麦谷物和相关产品是多酚化合物的良好来源,具有巨大的心脏保护潜力。全麦粒的多酚提取物含有不同的酚类化合物,即阿魏酸、咖啡酸、绿原酸、对香豆酸、山奈酸、丁香酸、香草酸、芹菜素、槲皮素、木犀草素等,它们通过减少氧化应激和干扰不同的毒性过程来发挥保护心脏的作用。抗氧化能力一直被认为是小麦多酚保护心脏的机制,它主要通过下调几种致病信号事件来抑制氧化应激、炎症和纤维化。然而,多酚的综合效应似乎比单一分子的效应更为突出,这可能是由于多种酚类物质的协同作用产生了多模式的心脏保护益处。本文论述了小麦多酚的生物可及性和可能对多种心血管疾病产生的保护作用。这篇综述讨论了单个小麦多酚对心血管系统的机理药理学。文章还强调了多酚提取物相对于单一酚类的优越性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Unrevealing the mechanisms behind the cardioprotective effect of wheat polyphenolics

Cardiovascular diseases pose a major threat to both life expectancy and quality of life worldwide, and a concerning level of disease burden has been attained, particularly in middle- and low-income nations. Several drugs presently in use lead to multiple adverse events. Thus, it is urgently needed to develop safe, affordable, and effective management of cardiovascular diseases. Emerging evidence reveals a positive association between polyphenol consumption and cardioprotection. Whole wheat grain and allied products are good sources of polyphenolic compounds bearing enormous cardioprotective potential. Polyphenolic extract of the entire wheat grain contains different phenolic compounds viz. ferulic acid, caffeic acid, chlorogenic acid, p-coumaric acid, sinapic acid, syringic acid, vanillic acid, apigenin, quercetin, luteolin, etc. which exert cardioprotection by reducing oxidative stress and interfering with different toxicological processes. The antioxidant capacity has been thought to exert the cardioprotective mechanism of wheat grain polyphenolics, which predominantly suppresses oxidative stress, inflammation and fibrosis by downregulating several pathogenic signaling events. However, the combined effect of polyphenolics appears to be more prominent than that of a single molecule, which might be attained due to the synergy resulting in multimodal cardioprotective benefits from multiple phenolics. The current article covers the bioaccessibility and possible effects of wheat-derived polyphenolics in protecting against several cardiovascular disorders. This review discusses the mechanistic pharmacology of individual wheat polyphenols on the cardiovascular system. It also highlights the comparative superiority of polyphenolic extracts over a single phenolic.

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来源期刊
Archives of Toxicology
Archives of Toxicology 医学-毒理学
CiteScore
11.60
自引率
4.90%
发文量
218
审稿时长
1.5 months
期刊介绍: Archives of Toxicology provides up-to-date information on the latest advances in toxicology. The journal places particular emphasis on studies relating to defined effects of chemicals and mechanisms of toxicity, including toxic activities at the molecular level, in humans and experimental animals. Coverage includes new insights into analysis and toxicokinetics and into forensic toxicology. Review articles of general interest to toxicologists are an additional important feature of the journal.
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