饮茶对抑郁症风险的影响:孟德尔随机和贝叶斯加权算法研究。

IF 1.3 4区 医学 Q4 NUTRITION & DIETETICS Asia Pacific journal of clinical nutrition Pub Date : 2024-12-01 DOI:10.6133/apjcn.202412_33(4).0010
Guifeng Zhuo, Wei Chen, Jinzhi Zhang, Mingyang Su, Xiaomin Zhu, Shanshan Pu, Naibing Liao, Deqing Huang, Xiangyi Chen, Lin Wu
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引用次数: 0

摘要

背景和目的:饮茶对抑郁症风险的确切影响仍不清楚。本研究旨在利用双样本孟德尔随机化(MR)方法,探讨茶叶消费模式与抑郁症发病可能性之间的关系:我们利用现有的茶叶摄入量和抑郁症的全基因组关联研究(GWAS)数据集。为了研究茶叶摄入量与抑郁症之间的因果关系,我们采用了一套双样本孟德尔随机化(MR)方法。这些方法包括逆方差加权(IVW)分析法、加权中位数法和 MR-Egger 回归法。此外,我们还利用 MR-PRESSO 和 MR-Egger 截距检验来检测多向效应。为确保研究结果的稳健性和一致性,我们采用 "留一剔除 "策略进行了敏感性分析。此外,还采用了贝叶斯加权孟德尔随机化(BWMR)对所获结果进行了额外测试:研究结果表明,茶叶摄入量的增加与抑郁症风险的增加之间存在因果关系(逆方差加权分析:Odds Ratio [OR] = 1):赔率比 [OR] = 1.029,95% 置信区间 [CI]:1.003-1.055):1.003-1.055, p = 0.027).尽管工具变量存在差异,且不存在水平多效性,但仍能观察到这一结果。此外,我们在敏感性分析中采用了 "撇一除一 "的方法,从而证实了孟德尔随机调查的稳健性。BWMR的结果与IVW的结果一致(BWMR:OR=1.030,95% CI:1.003-1.057,p = 0.029):本研究结果表明,经常饮茶与抑郁症发病风险之间存在实质性的正向因果关系。
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The impact of tea consumption on the risk of depression: A Mendelian randomization and Bayesian weighting algorithm study.

Background and objectives: The precise impact of tea consumption on the risk of depression remains unclear. This study aimed to explore the relationship between the consumption patterns of tea and the likelihood of depression onset, utilizing a two-sample Mendelian randomization (MR) methodology.

Methods and study design: We utilized available genome-wide association study (GWAS) datasets on tea intake and depressive disorders. To investigate the causal relationship between tea consumption and depression, we employed a set of two-sample Mendelian Randomization (MR) methods. These included the inverse-variance weighted (IVW) analysis, weighted median approach, and MR-Egger regression. Additionally, we utilized MR-PRESSO and the MR-Egger intercept test for the detection of pleiotropic effects. To ensure the robustness and consistency of our findings, a sensitivity analysis was carried out, applying the 'leave-one-out' strategy. The Bayesian weighted Mendelian randomization (BWMR) was employed to conduct additional testing on the obtained results.

Results: The study's outcomes revealed a causal association between increased tea intake and an increased risk of depression (Inverse-Variance Weighted Analysis: Odds Ratio [OR] = 1.029, 95% Confidence Interval [CI]: 1.003-1.055, p = 0.027). This was observed despite variations in instrumental variables and the nonexistence of horizontal pleiotropy. Furthermore, the robustness of our Mendelian Randomization investigation was affirmed through the implementation of the 'leave-one-out' method in our sensitivity analysis. The findings from BWMR were in line with those obtained from IVW (BWMR: OR=1.030, 95% CI: 1.003-1.057, p = 0.029).

Conclusions: The results from this study indicate a substantial and positive causal link between the regularity of tea drinking and the risk of depression onset.

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来源期刊
CiteScore
2.50
自引率
7.70%
发文量
58
审稿时长
6-12 weeks
期刊介绍: The aims of the Asia Pacific Journal of Clinical Nutrition (APJCN) are to publish high quality clinical nutrition relevant research findings which can build the capacity of clinical nutritionists in the region and enhance the practice of human nutrition and related disciplines for health promotion and disease prevention. APJCN will publish original research reports, reviews, short communications and case reports. News, book reviews and other items will also be included. The acceptance criteria for all papers are the quality and originality of the research and its significance to our readership. Except where otherwise stated, manuscripts are peer-reviewed by at least two anonymous reviewers and the Editor. The Editorial Board reserves the right to refuse any material for publication and advises that authors should retain copies of submitted manuscripts and correspondence as material cannot be returned. Final acceptance or rejection rests with the Editorial Board
期刊最新文献
Nutritional therapy among adult patients with severe burns: A retrospective observational study. Resting energy expenditure in patients with liver cirrhosis: Indirect calorimetry vs. predictive equations. Risk or associated factors of wasting among under-five children in Bangladesh: A systematic review. The impact of tea consumption on the risk of depression: A Mendelian randomization and Bayesian weighting algorithm study. A nomogram for predicting nutritional risk before gastric cancer surgery.
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