社区服务的使用对老年抑郁症的影响:一项为期十年的跟踪研究。

IF 3.4 2区 医学 Q2 GERIATRICS & GERONTOLOGY BMC Geriatrics Pub Date : 2024-08-30 DOI:10.1186/s12877-024-05290-w
Xiaowen Li, Yuanqing He, Shuhu Chen, Jun Zhang
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引用次数: 0

摘要

研究背景本研究探讨环境因素(社区服务使用情况,CSU)对老年抑郁症的影响是否由心理复原力介导,并受COMT(儿茶酚-O-甲基转移酶)基因val158met多态性的调节:数据来自中国健康长寿纵向调查(CLHLS)的13512个条目,收集时间分别为2008年、2011年、2014年和2018年。研究采用随机截距交叉滞后面板模型(RI-CLPM)来考察CSU与老年抑郁之间的关系,包括心理弹性的中介效应和comt基因val158met基因多态性在这一关系中的调节作用:结果发现,早期评估中较低的CSU与随后评估中更严重的老年抑郁有明显关联。心理复原力被发现部分介导了CSU与抑郁之间的关系。在不同基因型之间观察到了不同的影响;具体而言,与met基因型相比,val基因型的CSU对随后的心理复原力和抑郁的影响明显更大:结论:CSU的增强可预测老年抑郁症的发生。CSU与抑郁之间的关系可由心理复原力中介,遗传学调节了从CSU到心理复原力再到抑郁的路径。以提高社区服务质量、增强心理复原力和减轻抑郁为重点的多学科干预措施很可能有益于老年人的情绪和心理健康。
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The impact of community services usage on geriatric depression: a ten-year follow-up study.

Background: This study explores whether the impact of environmental factors (community services usage, CSU) on geriatric depression is mediated by psychological resilience and moderated by the COMT (catechol-O-methyltransferase) gene val158met polymorphism.

Methods: The data consists of 13,512 entries from the Chinese Longitudinal Healthy Longevity Survey (CLHLS) collected in the years 2008, 2011, 2014, and 2018. The study employed a Random Intercept Cross-Lagged Panel Model (RI-CLPM) to examine the relationship between CSU and geriatric depression, including the mediating effect of psychological resilience and the moderating role of the comt gene val158met gene polymorphism in this relationship.

Results: Lower CSU at earlier assessments were significantly associated with more severe geriatric depression in subsequent evaluations.Psychological resilience was found to partially mediate the relationship between CSU and depression.Differential impacts were observed among various gene genotypes; specifically, the val genotype demonstrated a significantly greater influence of CSU on subsequent psychological resilience and on subsequent depression compared to the met genotype.

Conclusion: Enhancement in CSU can predict subsequent geriatric depression. The relationship between the CSU and depression can be mediated by psychological resilience, with genetics modulating the pathway from CSU through psychological resilience to depression. Multidisciplinary interventions focused on enhancing community service quality, boosting psychological resilience, and mitigating depression are likely to benefit the older adults's emotional and psychological well-being.

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来源期刊
BMC Geriatrics
BMC Geriatrics GERIATRICS & GERONTOLOGY-
CiteScore
5.70
自引率
7.30%
发文量
873
审稿时长
20 weeks
期刊介绍: BMC Geriatrics is an open access journal publishing original peer-reviewed research articles in all aspects of the health and healthcare of older people, including the effects of healthcare systems and policies. The journal also welcomes research focused on the aging process, including cellular, genetic, and physiological processes and cognitive modifications.
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