{"title":"血清钙与颈动脉粥样硬化的关系：一项荟萃分析。","authors":"Huan Li, Ruicai Xu, Yizhi Liu, Yanli Dong, Dongyue He, Xiaohui Liu, Qinjian Sun, Xuena Liu","doi":"10.1159/000541132","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Current studies on the association between serum calcium levels and carotid atherosclerosis have yielded inconsistent results. This study aims to elucidate this relationship through a comprehensive meta-analysis.</p><p><strong>Methods: </strong>A systematic search of PubMed, Embase, Cochrane library, Scopus, Web of Science, China National Knowledge Infrastructure (CNKI), Chinese Biomedical Literature Database (CBM), Weipu (VIP), and Wanfang databases was conducted, supplemented by manual retrieval, from their inception to October 2023. Two independent researchers conducted literature searches, data extraction, and quality assessment. Meta-analysis was performed using Review Manager 5.3 software on studies that met the inclusion criteria.</p><p><strong>Results: </strong>The analysis included 9 cross-sectional studies, encompassing a total sample size of 9720 participants. The meta-analysis revealed a significant statistical difference in serum calcium levels between the carotid atherosclerosis group and the control group(P = 0.03). The standardized mean difference between the two groups was 0.21 (95% CI: 0.02,0.41) using the control group as a reference.</p><p><strong>Conclusions: </strong>Our systematic analysis indicates a significant positive correlation between serum calcium levels and carotid atherosclerosis.</p>","PeriodicalId":9683,"journal":{"name":"Cerebrovascular Diseases","volume":null,"pages":null},"PeriodicalIF":2.2000,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Association of serum calcium with carotid atherosclerosis: a meta-analysis.\",\"authors\":\"Huan Li, Ruicai Xu, Yizhi Liu, Yanli Dong, Dongyue He, Xiaohui Liu, Qinjian Sun, Xuena Liu\",\"doi\":\"10.1159/000541132\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Current studies on the association between serum calcium levels and carotid atherosclerosis have yielded inconsistent results. This study aims to elucidate this relationship through a comprehensive meta-analysis.</p><p><strong>Methods: </strong>A systematic search of PubMed, Embase, Cochrane library, Scopus, Web of Science, China National Knowledge Infrastructure (CNKI), Chinese Biomedical Literature Database (CBM), Weipu (VIP), and Wanfang databases was conducted, supplemented by manual retrieval, from their inception to October 2023. Two independent researchers conducted literature searches, data extraction, and quality assessment. Meta-analysis was performed using Review Manager 5.3 software on studies that met the inclusion criteria.</p><p><strong>Results: </strong>The analysis included 9 cross-sectional studies, encompassing a total sample size of 9720 participants. The meta-analysis revealed a significant statistical difference in serum calcium levels between the carotid atherosclerosis group and the control group(P = 0.03). The standardized mean difference between the two groups was 0.21 (95% CI: 0.02,0.41) using the control group as a reference.</p><p><strong>Conclusions: </strong>Our systematic analysis indicates a significant positive correlation between serum calcium levels and carotid atherosclerosis.</p>\",\"PeriodicalId\":9683,\"journal\":{\"name\":\"Cerebrovascular Diseases\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2024-08-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cerebrovascular Diseases\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1159/000541132\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cerebrovascular Diseases","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1159/000541132","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Association of serum calcium with carotid atherosclerosis: a meta-analysis.
Introduction: Current studies on the association between serum calcium levels and carotid atherosclerosis have yielded inconsistent results. This study aims to elucidate this relationship through a comprehensive meta-analysis.
Methods: A systematic search of PubMed, Embase, Cochrane library, Scopus, Web of Science, China National Knowledge Infrastructure (CNKI), Chinese Biomedical Literature Database (CBM), Weipu (VIP), and Wanfang databases was conducted, supplemented by manual retrieval, from their inception to October 2023. Two independent researchers conducted literature searches, data extraction, and quality assessment. Meta-analysis was performed using Review Manager 5.3 software on studies that met the inclusion criteria.
Results: The analysis included 9 cross-sectional studies, encompassing a total sample size of 9720 participants. The meta-analysis revealed a significant statistical difference in serum calcium levels between the carotid atherosclerosis group and the control group(P = 0.03). The standardized mean difference between the two groups was 0.21 (95% CI: 0.02,0.41) using the control group as a reference.
Conclusions: Our systematic analysis indicates a significant positive correlation between serum calcium levels and carotid atherosclerosis.
期刊介绍：
A rapidly-growing field, stroke and cerebrovascular research is unique in that it involves a variety of specialties such as neurology, internal medicine, surgery, radiology, epidemiology, cardiology, hematology, psychology and rehabilitation. ''Cerebrovascular Diseases'' is an international forum which meets the growing need for sophisticated, up-to-date scientific information on clinical data, diagnostic testing, and therapeutic issues, dealing with all aspects of stroke and cerebrovascular diseases. It contains original contributions, reviews of selected topics and clinical investigative studies, recent meeting reports and work-in-progress as well as discussions on controversial issues. All aspects related to clinical advances are considered, while purely experimental work appears if directly relevant to clinical issues.
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