确诊为坏死性小肠结肠炎的早产儿的母乳微生物群、寡糖谱和婴儿肠道微生物群。

IF 11.7 1区 医学 Q1 CELL BIOLOGY Cell Reports Medicine Pub Date : 2024-09-17 Epub Date: 2024-08-30 DOI:10.1016/j.xcrm.2024.101708
Andrea C Masi, Lauren C Beck, John D Perry, Claire L Granger, Alice Hiorns, Gregory R Young, Lars Bode, Nicholas D Embleton, Janet E Berrington, Christopher J Stewart
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摘要

坏死性小肠结肠炎(NEC)是极早产儿的一种严重肠道疾病,母乳(MOM)可提供保护,但 MOM 微生物群对 NEC 风险的影响尚未得到探讨。在此,我们通过一项横断面研究分析了 110 名早产儿(48 名 NEC,62 名对照组)的母乳微生物群。母乳中含有可存活的细菌,但 NEC 和对照组之间的 MOM 微生物群没有显著差异。MOM 微生物群、母乳低聚糖(HMOs)和婴儿肠道微生物群之间的综合分析表明,婴儿肠道中的醋杆菌与 MOM 中的醋杆菌和葡萄球菌之间存在正相关。这项研究表明,MOM 对 NEC 的保护作用并不是通过 MOM 微生物群来调节的。因此,"恢复 "供体母乳中的 MOM 微生物群不太可能减少 NEC,重点应放在增加新鲜母体母乳摄入量和研究不同的 NEC 预防疗法上。
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Human milk microbiota, oligosaccharide profiles, and infant gut microbiome in preterm infants diagnosed with necrotizing enterocolitis.

Necrotizing enterocolitis (NEC) is a severe intestinal disease of very preterm infants with mother's own milk (MOM) providing protection, but the contribution of the MOM microbiota to NEC risk has not been explored. Here, we analyze MOM of 110 preterm infants (48 NEC, 62 control) in a cross-sectional study. Breast milk contains viable bacteria, but there is no significant difference in MOM microbiota between NEC and controls. Integrative analysis between MOM microbiota, human milk oligosaccharides (HMOs), and the infant gut microbiota shows positive correlations only between Acinetobacter in the infant gut and Acinetobacter and Staphylococcus in MOM. This study suggests that NEC protection from MOM is not modulated through the MOM microbiota. Thus, "'restoring" the MOM microbiota in donor human milk is unlikely to reduce NEC, and emphasis should instead focus on increasing fresh maternal human milk intake and researching different therapies for NEC prevention.

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来源期刊
Cell Reports Medicine
Cell Reports Medicine Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)
CiteScore
15.00
自引率
1.40%
发文量
231
审稿时长
40 days
期刊介绍: Cell Reports Medicine is an esteemed open-access journal by Cell Press that publishes groundbreaking research in translational and clinical biomedical sciences, influencing human health and medicine. Our journal ensures wide visibility and accessibility, reaching scientists and clinicians across various medical disciplines. We publish original research that spans from intriguing human biology concepts to all aspects of clinical work. We encourage submissions that introduce innovative ideas, forging new paths in clinical research and practice. We also welcome studies that provide vital information, enhancing our understanding of current standards of care in diagnosis, treatment, and prognosis. This encompasses translational studies, clinical trials (including long-term follow-ups), genomics, biomarker discovery, and technological advancements that contribute to diagnostics, treatment, and healthcare. Additionally, studies based on vertebrate model organisms are within the scope of the journal, as long as they directly relate to human health and disease.
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