在注射 XBB.1.5 mRNA 疫苗强化剂后的 6 个月内,SARS-CoV-2 中和抗体一直保持稳定。

IF 11.7 1区 医学 Q1 CELL BIOLOGY Cell Reports Medicine Pub Date : 2024-09-17 Epub Date: 2024-08-28 DOI:10.1016/j.xcrm.2024.101701
Qian Wang, Ian A Mellis, Yicheng Guo, Carmen Gherasim, Riccardo Valdez, Aubree Gordon, David D Ho, Lihong Liu
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引用次数: 0

摘要

注射 XBB.1.5 单价 mRNA 疫苗(XBB.1.5 MV)加强针 1 个月后,严重急性呼吸系统综合征冠状病毒 2(SARS-CoV-2)中和抗体会大幅增加,但这种反应的持久性仍然未知。为了解决这个问题,我们使用参与者在注射 XBB.1.5 MV 加强剂后 1 个月、3 个月和 6 个月获得的血清对四种病毒变体(D614G、BA.5、XBB.1.5 和 JN.1)进行了中和检测。我们的研究结果表明,由此产生的中和抗体滴度很强,在研究期间通常保持在稳定水平,与感染 XBB 后的抗体滴度相似。重要的是,这种中和抗体滴度的持久性与原始单价或 BA.5 二价 mRNA 疫苗强化后观察到的抗体滴度下降形成了鲜明对比。我们的研究结果与美国疾病控制和预防中心最近的国家数据相一致,后者的数据显示,XBB.1.5 MV 强化接种后,对无症状 SARS-CoV-2 感染的疗效可维持长达 4 个月。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Robust SARS-CoV-2-neutralizing antibodies sustained through 6 months post XBB.1.5 mRNA vaccine booster.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-neutralizing antibodies are substantially expanded 1 month after a shot of XBB.1.5 monovalent mRNA vaccine (XBB.1.5 MV) booster, but the durability of this response remains unknown. Here, we address this question by performing neutralization assays on four viral variants (D614G, BA.5, XBB.1.5, and JN.1) using sera from participants obtained at ∼1 month, ∼3 months, and ∼6 months post an XBB.1.5 MV booster. Our findings indicate that the resulting neutralizing antibody titers are robust and generally remain at stable levels for the study period, similar to those following XBB infection. Importantly, this durability of neutralizing antibody titers contrasts with the decline observed after a booster of the original monovalent or BA.5 bivalent mRNA vaccine. Our results are in line with the recent national data from the Centers for Disease Control and Prevention, showing that the efficacy against symptomatic SARS-CoV-2 infection is sustained for up to 4 months after an XBB.1.5 MV booster.

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来源期刊
Cell Reports Medicine
Cell Reports Medicine Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)
CiteScore
15.00
自引率
1.40%
发文量
231
审稿时长
40 days
期刊介绍: Cell Reports Medicine is an esteemed open-access journal by Cell Press that publishes groundbreaking research in translational and clinical biomedical sciences, influencing human health and medicine. Our journal ensures wide visibility and accessibility, reaching scientists and clinicians across various medical disciplines. We publish original research that spans from intriguing human biology concepts to all aspects of clinical work. We encourage submissions that introduce innovative ideas, forging new paths in clinical research and practice. We also welcome studies that provide vital information, enhancing our understanding of current standards of care in diagnosis, treatment, and prognosis. This encompasses translational studies, clinical trials (including long-term follow-ups), genomics, biomarker discovery, and technological advancements that contribute to diagnostics, treatment, and healthcare. Additionally, studies based on vertebrate model organisms are within the scope of the journal, as long as they directly relate to human health and disease.
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