利用 FDG-PET/CT 健康检查数据分析韩国成年人与年龄相关的身体成分变化和代谢模式。

IF 6.8 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Diabetes & Metabolism Journal Pub Date : 2024-09-02 DOI:10.4093/dmj.2024.0057
Chang-Myung Oh, Ji-In Bang, Sang Yoon Lee, Jae Kyung Lee, Jee Won Chai, So Won Oh
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引用次数: 0

摘要

背景:F-18-氟脱氧葡萄糖正电子发射断层扫描(FDG-PET)/计算机断层扫描(CT)可用于测量骨矿物质密度(BMD)、横断面肌肉面积(CSMA)、肝脏和肌肉的侯菲尔德单位(HU)、皮下脂肪组织(SAT)、腹部内脏脂肪组织(VAT)以及糖代谢。本研究旨在利用机会性 FDG-PET/CT 成像确定韩国人身体成分和糖代谢与年龄有关的变化:我们分析了 2017 年至 2022 年期间在一家机构接受健康检查的患者病历中摘录的 FDG-PET/CT、临床病史和实验室数据:共有278名患者纳入分析(男女比例为140:138)。女性的年龄与体重指数呈正相关,男性则呈负相关。女性的 BMD 随年龄的增长而减少,男性的 CSMA 随年龄的增长而减少。随着年龄的增长,男性和女性的肌肉密度都有所下降。在女性中,SAT 和 VAT 随年龄增长而增加;在男性中,SAT 略有下降,而 VAT 保持稳定。男性的肌肉糖代谢与年龄无关,但女性的肌肉糖代谢随年龄增长而增加。总体而言,CSMA 与 BMD 呈正相关;仅在男性中,CSMA 与 VAT 和 SAT 呈正相关。仅在女性中,SAT 和 VAT 与葡萄糖代谢呈负相关,而与肌肉葡萄糖代谢呈正相关。肝脏 HU 值与 VAT 呈反相关,尤其是女性;仅女性与肌肉葡萄糖代谢呈正相关:结论:FDG-PET/CT 显示了与年龄相关的身体成分和葡萄糖代谢变化的独特模式,男女之间存在显著差异。
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An Analysis of Age-Related Body Composition Changes and Metabolic Patterns in Korean Adults Using FDG-PET/CT Health Screening Data.

Background: F-18-fluorodeoxyglucose positron emission tomography (FDG-PET)/computed tomography (CT) can be used to measure bone mineral density (BMD), cross-sectional muscle area (CSMA), Hounsfield units (HU) of liver and muscle, subcutaneous adipose tissue (SAT), abdominal visceral adipose tissue (VAT), and glucose metabolism. The present study aimed to identify age-related changes in body composition and glucose metabolism in Korean using opportunistic FDG-PET/CT imaging.

Methods: We analyzed FDG-PET/CT, clinical history, and laboratory data abstracted from the medical records of patients who underwent health screening at a single institute between 2017 and 2022.

Results: In total, 278 patients were included in the analysis (male:female=140:138). Age and body mass index were positively correlated in female, but negatively correlated in male. BMD decreased with age more in female, and CSMA decreased with age more in male. Muscle HU decreased with age for both sexes. In female, SAT and VAT increased with age; and in male, SAT decreased slightly while VAT remained stable. Muscle glucose metabolism showed no association with age in male but increased with age in female. CSMA correlated positively with BMD overall; and positively correlated with VAT and SAT in male only. In female only, both SAT and VAT showed negative correlations with glucose metabolism and correlated positively with muscle glucose metabolism. Liver HU values were inversely correlated with VAT, especially in female; and positively correlated with muscle glucose metabolism in female only.

Conclusion: FDG-PET/CT demonstrated distinct patterns of age-related changes in body composition and glucose metabolism, with significant differences between sexes.

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来源期刊
Diabetes & Metabolism Journal
Diabetes & Metabolism Journal Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
10.40
自引率
6.80%
发文量
92
审稿时长
52 weeks
期刊介绍: The aims of the Diabetes & Metabolism Journal are to contribute to the cure of and education about diabetes mellitus, and the advancement of diabetology through the sharing of scientific information on the latest developments in diabetology among members of the Korean Diabetes Association and other international societies. The Journal publishes articles on basic and clinical studies, focusing on areas such as metabolism, epidemiology, pathogenesis, complications, and treatments relevant to diabetes mellitus. It also publishes articles covering obesity and cardiovascular disease. Articles on translational research and timely issues including ubiquitous care or new technology in the management of diabetes and metabolic disorders are welcome. In addition, genome research, meta-analysis, and randomized controlled studies are welcome for publication. The editorial board invites articles from international research or clinical study groups. Publication is determined by the editors and peer reviewers, who are experts in their specific fields of diabetology.
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