肥胖会加重 C 反应蛋白对膝关节疼痛的影响:利用 NHANES 数据进行的横断面分析。

IF 3.1 4区 医学 Q3 IMMUNOLOGY Immunity, Inflammation and Disease Pub Date : 2024-09-02 DOI:10.1002/iid3.1371
Ling Luo, Mingzi Li, Wenlong Huang, Siying Zhang, Jianbo Sun, Bingsong Zhang, Wei Hu, Haibing Yu
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引用次数: 0

摘要

目的研究 C 反应蛋白(CRP)与膝关节疼痛之间的关系,并进一步探讨这种关系是否由肥胖介导:方法:研究人群来自 1999 年至 2004 年全国健康与营养调查。方法:研究对象来自 1999 年至 2004 年的全国健康与营养调查,采用三种不同的逻辑回归模型分析 CRP 与膝关节疼痛之间的关系,并分析其线性趋势。限制性立方样条模型用于评估 CRP 与膝关节疼痛之间的非线性剂量-反应关系。中介分析用于评估肥胖的潜在中介作用。为确保稳健性,还进行了分组分析和敏感性分析:与 CRP 较低的成人(第一四分位数)相比,CRP 较高的成人发生膝关节疼痛的风险较高(第三四分位数的几率比为 1.39,95% 置信区间为 1.12-1.72;第四四分位数的几率比为 1.56,1.25-1.95),调整协变量(体重指数 [BMI]除外)后,由体重指数介导的比例为 76.10%(P 结论:肥胖介导了全身性疼痛的结果:肥胖对美国成年人膝关节疼痛的全身炎症结果具有中介作用。此外,在不同程度的 CRP 亚组中,较高的体重指数与较高的膝关节疼痛风险相关,这支持了减肥在减少全身炎症引起的膝关节疼痛中的重要作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Obesity aggravates the role of C-reactive protein on knee pain: A cross-sectional analysis with NHANES data

Objective

To examine the relationship between C-reactive protein (CRP) and knee pain, and further explore whether this association is mediated by obesity.

Methods

The population was derived from 1999 to 2004 National Health and Nutrition Examination Survey. Logistic regression was used to analyze the relationship between CRP and knee pain in three different models, and the linear trend was analyzed. A restricted cubic spline model to assess the nonlinear dose−response relationship between CRP and knee pain. Mediation analyses were used to assess the potential mediating role of obesity. Subgroup analyses and sensitivity analyses were performed to ensure robustness.

Results

Compared with adults with lower CRP (first quartile), those with higher CRP had higher risks of knee pain (odds ratio 1.39, 95% confidence interval 1.12−1.72 in third quartile; 1.56, 1.25−1.95 in fourth quartile) after adjusting for covariates (except body mass index [BMI]), and the proportion mediated by BMI was 76.10% (p < .001). BMI and CRP were linear dose−response correlated with knee pain. The odds ratio for those with obesity compared with normal to knee pain was 2.27 (1.42−3.65) in the first quartile of CRP, 1.99 (1.38−2.86) in the second, 2.15 (1.38−3.33) in the third, and 2.92 (1.72−4.97) in the fourth.

Conclusion

Obesity mediated the systemic inflammation results in knee pain in US adults. Moreover, higher BMI was associated with higher knee pain risk in different degree CRP subgroups, supporting an important role of weight loss in reducing knee pain caused by systemic inflammation.

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来源期刊
Immunity, Inflammation and Disease
Immunity, Inflammation and Disease Medicine-Immunology and Allergy
CiteScore
3.60
自引率
0.00%
发文量
146
审稿时长
8 weeks
期刊介绍: Immunity, Inflammation and Disease is a peer-reviewed, open access, interdisciplinary journal providing rapid publication of research across the broad field of immunology. Immunity, Inflammation and Disease gives rapid consideration to papers in all areas of clinical and basic research. The journal is indexed in Medline and the Science Citation Index Expanded (part of Web of Science), among others. It welcomes original work that enhances the understanding of immunology in areas including: • cellular and molecular immunology • clinical immunology • allergy • immunochemistry • immunogenetics • immune signalling • immune development • imaging • mathematical modelling • autoimmunity • transplantation immunology • cancer immunology
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