不同放射学大小的牙泡中表皮生长因子受体和人类表皮生长因子受体 2 的免疫组化表达比较。

IF 1.6 Q2 MEDICINE, GENERAL & INTERNAL Iranian Journal of Medical Sciences Pub Date : 2024-08-01 DOI:10.30476/IJMS.2023.98602.3121
Shirin Saravani, Hamed Nemati Rezvani, Mehrdad Shahraki, Hamideh Kadeh
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引用次数: 0

摘要

背景:牙源性囊肿和肿瘤是从无症状的阻生牙的牙泡中生长出来的。牙源性组织表达表皮生长因子受体家族(EGFR),该家族介导细胞增殖、存活和肿瘤分化。本研究旨在比较正常和影像学大小异常的阻生智齿牙槽窝中表皮生长因子受体(EGFR)和人表皮生长因子受体 2(HER2)的免疫组化表达情况:在这项分析研究中,对影响第三磨牙的 30 个正常和 30 个异常牙泡进行了表皮生长因子受体(EGFR)和人表皮生长因子受体 2(HER2)的免疫组化染色。卵泡宽度分别采用 t 检验和 Chi square 检验。结果:所有正常和异常卵泡的表皮生长因子受体(EGFR)和表皮生长因子受体(HER2)总体表达量都很高。正常卵泡和异常卵泡中染色细胞的百分比以及表皮生长因子受体和 HER2 染色强度的比较无显著差异(分别为 P=0.73、P=0.63、P=0.95):由于表皮生长因子受体(EGFR)和 HER2 在正常和异常毛囊中的高表达以及两组间无明显差异,牙科毛囊的影像学大小可能并不代表其细胞的潜在能力,建议在该领域开展更多研究。
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A Comparison of Immunohistochemical Expression of Epidermal Growth Factor Receptor and Human Epidermal Growth Factor Receptor 2 in Dental Follicles with Different Radiographic Sizes.

Background: Odontogenic cysts and tumors develop from the dental follicle of asymptomatic impacted teeth. Odontogenic tissues express the epidermal growth factor receptor family (EGFR), which mediates cell proliferation, survival, and neoplastic differentiation. The present study aimed to compare the immunohistochemical expression of EGFR and human epidermal growth factor receptor 2 (HER2) in the dental follicle of impacted wisdom teeth with normal and abnormal radiographic size.

Methods: In this analytical study, immunohistochemical staining of EGFR and HER2 was performed on 30 normal and 30 abnormal follicles of impacted third molars. Follicles with a width of <2.5 mm were considered normal, whereas those with a width of ≥2.5 mm were regarded as abnormal. The immunoreactive score (IRS) was used to report the expression levels of EGFR and HER2. The obtained data were analyzed using SPSS software. Age and sex were compared in normal and abnormal groups with independent t test and Chi square test, respectively. P<0.05 was considered statistically significant.

Results: The EGFR and HER2 overall expression was high in all normal and abnormal follicles. The comparison of the percentage of stained cells and intensity of EGFR and HER2 staining in normal and abnormal follicles were not significantly different (P=0.73, P=0.63, P=0.95, respectively).

Conclusion: Due to the high expression of EGFR and HER2 in normal and abnormal follicles, as well as the lack of significant differences in these two groups, the radiographic size of dental follicles might not indicate the potential capabilities of their cells, and more research in this field is recommended.

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来源期刊
Iranian Journal of Medical Sciences
Iranian Journal of Medical Sciences MEDICINE, GENERAL & INTERNAL-
CiteScore
3.20
自引率
0.00%
发文量
84
审稿时长
12 weeks
期刊介绍: The Iranian Journal of Medical Sciences (IJMS) is an international quarterly biomedical publication, which is sponsored by Shiraz University of Medical Sciences. The IJMS intends to provide a scientific medium of com­muni­cation for researchers throughout the globe. The journal welcomes original clinical articles as well as clinically oriented basic science re­search experiences on prevalent diseases in the region and analysis of various regional problems.
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