{"title":"EWSR1：间充质肿瘤的杂交之王。","authors":"Emily Anne Towery, David James Papke","doi":"10.1136/jcp-2023-208867","DOIUrl":null,"url":null,"abstract":"<p><p><i>EWSR1</i> is the most commonly rearranged gene in mesenchymal neoplasia, and its myriad chimeric oncoproteins drive widely disparate neoplasms. Here, we survey selected <i>EWSR1</i> rearrangements, including well-described <i>EWSR1</i> fusions with CREB family members, <i>ATF1</i> and <i>CREB1</i>, as well as fusions in emerging entities such as mesenchymal neoplasms with <i>EWSR1::PATZ1</i> and <i>EWSR1::NFATC2</i> fusions. We also discuss recent data demonstrating the imperfect specificity of <i>EWSR1::WT1</i> and, possibly, <i>EWSR1::FLI1</i> fusions.</p>","PeriodicalId":15391,"journal":{"name":"Journal of Clinical Pathology","volume":null,"pages":null},"PeriodicalIF":2.5000,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"<i>EWSR1</i>: the promiscuous king of mesenchymal neoplasia.\",\"authors\":\"Emily Anne Towery, David James Papke\",\"doi\":\"10.1136/jcp-2023-208867\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><i>EWSR1</i> is the most commonly rearranged gene in mesenchymal neoplasia, and its myriad chimeric oncoproteins drive widely disparate neoplasms. Here, we survey selected <i>EWSR1</i> rearrangements, including well-described <i>EWSR1</i> fusions with CREB family members, <i>ATF1</i> and <i>CREB1</i>, as well as fusions in emerging entities such as mesenchymal neoplasms with <i>EWSR1::PATZ1</i> and <i>EWSR1::NFATC2</i> fusions. We also discuss recent data demonstrating the imperfect specificity of <i>EWSR1::WT1</i> and, possibly, <i>EWSR1::FLI1</i> fusions.</p>\",\"PeriodicalId\":15391,\"journal\":{\"name\":\"Journal of Clinical Pathology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2024-08-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Clinical Pathology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1136/jcp-2023-208867\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"PATHOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Clinical Pathology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1136/jcp-2023-208867","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PATHOLOGY","Score":null,"Total":0}
EWSR1: the promiscuous king of mesenchymal neoplasia.
EWSR1 is the most commonly rearranged gene in mesenchymal neoplasia, and its myriad chimeric oncoproteins drive widely disparate neoplasms. Here, we survey selected EWSR1 rearrangements, including well-described EWSR1 fusions with CREB family members, ATF1 and CREB1, as well as fusions in emerging entities such as mesenchymal neoplasms with EWSR1::PATZ1 and EWSR1::NFATC2 fusions. We also discuss recent data demonstrating the imperfect specificity of EWSR1::WT1 and, possibly, EWSR1::FLI1 fusions.
期刊介绍：
Journal of Clinical Pathology is a leading international journal covering all aspects of pathology. Diagnostic and research areas covered include histopathology, virology, haematology, microbiology, cytopathology, chemical pathology, molecular pathology, forensic pathology, dermatopathology, neuropathology and immunopathology. Each issue contains Reviews, Original articles, Short reports, Correspondence and more.
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