懒惰的病毒还是受控的变形者？CTCF 驱动的染色质相互作用对 HCMV 基因表达的三维调控

IF 3.8 2区医学 Q2 VIROLOGY Journal of Virology Pub Date : 2024-10-22 Epub Date: 2024-08-30 DOI:10.1128/jvi.01148-24

Ian J Groves, Christine M O'Connor

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引用次数: 0

摘要

真核生物转录的三维染色质控制是调节基因表达的关键。包括疱疹病毒在内的 DNA 病毒也利用了这一额外的表观遗传调控层。动态的空间基因组组织通常涉及由宿主编码的 CCCTC 结合因子（CTCF）和其他因子锚定的染色质循环，这些因子控制着启动子和增强子之间的串扰。在此，我们回顾了 CTCF 介导的环状结构在疱疹病毒感染过程中调节转录的作用，并特别关注β疱疹病毒--人类巨细胞病毒（HCMV）。

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Loopy virus or controlled contortionist? 3D regulation of HCMV gene expression by CTCF-driven chromatin interactions.

Three-dimensional chromatin control of eukaryotic transcription is pivotal for regulating gene expression. This additional layer of epigenetic regulation is also utilized by DNA viruses, including herpesviruses. Dynamic, spatial genomic organization often involves looping of chromatin anchored by host-encoded CCCTC-binding factor (CTCF) and other factors, which control crosstalk between promoters and enhancers. Herein, we review the contribution of CTCF-mediated looping in regulating transcription during herpesvirus infection, with a specific focus on the betaherpesvirus, human cytomegalovirus (HCMV).

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来源期刊

Journal of Virology 医学-病毒学

CiteScore

10.10

自引率

7.40%

发文量

906

审稿时长

1 months

期刊介绍： Journal of Virology (JVI) explores the nature of the viruses of animals, archaea, bacteria, fungi, plants, and protozoa. We welcome papers on virion structure and assembly, viral genome replication and regulation of gene expression, genetic diversity and evolution, virus-cell interactions, cellular responses to infection, transformation and oncogenesis, gene delivery, viral pathogenesis and immunity, and vaccines and antiviral agents.